CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.
CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.
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DOI：
10.4049/jimmunol.1103032
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发表时间：
2012-09-01
期刊：
影响因子：
--
通讯作者：
Starnbach MN
中科院分区：
文献类型：
--
作者：
Gondek DC;Olive AJ;Stary G;Starnbach MN
沙眼衣原体感染是美国最常见的细菌性传播疾病。衣原体感染上升到上生殖道可以持续存在，引发炎症，并导致严重的后遗症，如不孕。然而，阴道穹窿接种沙眼衣原体的小鼠模型不能概括人类疾病的病程。小鼠的这些阴道内感染不会有效地上升到上生殖道，不会引起持续感染，不会诱导显著的炎症，也不会诱导显著的CD4+ T细胞浸润。在这里，我们描述了一个非侵入性经宫颈感染模型，我们绕过子宫颈，直接接种沙眼衣原体进入子宫。我们发现，直接感染沙眼衣原体的小鼠上生殖道刺激强大的衣原体特异性CD4+ T细胞反应，这是清除感染和提供防止再次感染的必要和充分的。
Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. Chlamydia infections that ascend to the upper genital tract can persist, trigger inflammation, and result in serious sequelae such as infertility. However, mouse models where the vaginal vault is inoculated with C. trachomatis do not recapitulate the course of human disease. These intravaginal infections of the mouse do not ascend efficiently to the upper genital tract, do not cause persistent infection, do not induce significant inflammation, and do not induce significant CD4+ T cell infiltration. Here we describe a non-invasive transcervical infection model where we bypass the cervix and directly inoculate C. trachomatis into the uterus. We show that direct C. trachomatis infection of the murine upper genital tract stimulates a robust Chlamydia-specific CD4+ T cell response that is both necessary and sufficient to clear infection and provide protection against re-infection.
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影响因子：
8
作者：
通讯作者：
--
DOI：
10.1111/j.1600-0897.2009.00704.x
发表时间：
2009-06-01
影响因子：
3.6
作者：
Kelly, Kathleen A.;Chan, Ann M.;Darville, Toni
通讯作者：
Darville, Toni
影响因子：
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通讯作者：
Black, Carolyn M.
影响因子：
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作者：
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通讯作者：
Darville, Toni
影响因子：
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作者：
Moniz, Raymond J.;Chan, Ann M.;Kelly, Kathleen A.
通讯作者：
Kelly, Kathleen A.