Interstitial assessment of aggressive prostate cancer by physio-chemical photoacoustics: An ex vivo study with intact human prostates.
Interstitial assessment of aggressive prostate cancer by physio-chemical photoacoustics: An ex vivo study with intact human prostates.
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通过物理化学光声学对侵袭性前列腺癌进行间质评估：对完整人类前列腺的离体研究。
DOI：
10.1002/mp.13061
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发表时间：
2018-06-23
期刊：
影响因子：
3.8
通讯作者：
Xu G
中科院分区：
文献类型：
--
作者：
Huang S;Qin Y;Chen Y;Pan J;Xu C;Wu D;Chao WY;Wei JT;Tomlins SA;Wang X;Fowlkes JB;Carson PL;Cheng Q;Xu G
经直肠超声 (TRUS) 引导活检是评估前列腺癌的存在和侵袭性的标准程序。 TRUS活检涉及组织切除，核心产量低，假阴性率高。因此，非常需要一种侵入性较小且更准确的前列腺癌诊断程序。光声（PA）技术结合光学灵敏度和超声分辨率来解析组织中主要分子成分的空间分布，可能成为诊断前列腺癌的另一种方法。本研究的目的是探讨使用间质 PA 测量来识别侵袭性前列腺癌的可行性。 17 名接受活检前磁共振成像 (MRI)、TRUS 活检和计划进行前列腺切除术的患者参与了这项研究。间质 PA 测量是使用我们最近开发的针 PA 探针实现的，该探针以活检针的方式插入离体前列腺。总共获得了 70 个间隙 PA 测量结果。 PA 测量值通过先前建立的 PA 理化分析 (PAPCA) 方法进行量化。组织学证实了插入位置的非侵袭性和侵袭性癌状况。诊断准确性也与活检前 MRI 提供的诊断准确性进行了比较。定量研究显示非侵袭性癌变区域和侵袭性癌变区域的个体参数之间存在显着差异（p<0.005）。定量特征的多变量分析在区分非侵袭性和侵袭性前列腺癌组织方面实现了 78.6% 的诊断准确度。所提出的程序在诊断侵袭性前列腺癌方面显示出了希望。
Transrectal ultrasound (TRUS) guided biopsy is the standard procedure for evaluating the presence and aggressiveness of prostate cancer. TRUS biopsy involves tissue removal, and suffers from low core yield as well as high false negative rate. A less invasive and more accurate diagnostic procedure for prostate cancer is therefore highly desired. Combining the optical sensitivity and ultrasonic resolution to resolve the spatial distribution of the major molecular components in tissue, photoacoustic (PA) technology could be an alternative approach for the diagns of prostate cancer. The purpose of this study is to examine the feasibility of identifying aggressive prostate cancer using interstitial PA measurements. 17 patients with pre-biopsy magnetic resonance imaging (MRI), TRUS biopsies and planned prostatectomies were enrolled in this study. The interstitial PA measurements were achieved using our recently developed needle PA probe, which was inserted into the ex vivo prostates in the fashion of a biopsy needle. A total of 70 interstitial PA measurements were acquired. The PA measurements were quantified by a previously established PA physio-chemical analysis (PAPCA) method. The histology has confirmed the nonaggressive and aggressive cancerous conditions at the insertion locations. The diagnostic accuracy was also compared to that provided by the pre-biopsy MRI. The quantitative study shows significant differences between the individual parameters of the nonaggressive and the aggressive cancerous regions (p<0.005). Multivariate analysis of the quantitative features achieved a diagnostic accuracy of 78.6% for differentiating nonaggressive and aggressive prostate cancer tissues. The proposed procedure has shown promises in the diagnosis of aggressive prostate cancer.
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影响因子：
2.1
作者：
Fiard, Gaelle;Hohn, Noelie;Long, Jean-Alexandre
通讯作者：
Long, Jean-Alexandre
影响因子：
--
作者：
Morrison, C;Thornhill, J;Gaffney, E
通讯作者：
Gaffney, E
影响因子：
3.5
作者：
Pu, Yang;Wang, Wubao;Alfano, Robert R.
通讯作者：
Alfano, Robert R.
影响因子：
0.9
作者：
Dogra VS;Chinni BK;Valluru KS;Joseph JV;Ghazi A;Yao JL;Evans K;Messing EM;Rao NA
通讯作者：
Rao NA
影响因子：
23.4
作者：
Siddiqui MM;Rais-Bahrami S;Truong H;Stamatakis L;Vourganti S;Nix J;Hoang AN;Walton-Diaz A;Shuch B;Weintraub M;Kruecker J;Amalou H;Turkbey B;Merino MJ;Choyke PL;Wood BJ;Pinto PA
通讯作者：
Pinto PA