Stochastic gene expression in mammals: lessons from olfaction.
Stochastic gene expression in mammals: lessons from olfaction.
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DOI：
10.1016/j.tcb.2013.04.005
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发表时间：
2013-09
影响因子：
19
通讯作者：
Lomvardas, Stavros
中科院分区：
文献类型：
--
作者：
Magklara, Angeliki;Lomvardas, Stavros
关键词：
高等生物的显著特征之一是，从一个共同的基因组中产生了大量不同类型的细胞。免疫系统肩负着检测数量惊人的病原体的艰巨任务，神经系统肩负着感知和解释外部世界的同样令人困惑的任务，它们是细胞多样性的精髓。正如我们几十年前开始认识到的那样，在相似的细胞类型中实现不同的表达程序不能仅仅通过确定性调控系统来完成，而是通过某种类型的随机性来完成。在过去的几年里，我们对这些不确定性机制的理解正在进步，本文将简要总结目前对随机基因表达的看法，重点是嗅觉受体基因选择，其表观遗传学基础最近开始出现。
One of the remarkable characteristics of higher organisms is the enormous assortment of cell types that emerge from a common genome. The immune system, with the daunting duty of detecting an astounding number of pathogens, and the nervous system with the equally bewildering task of perceiving and interpreting the external world, are the quintessence of cellular diversity. As we began to appreciate decades ago, achieving distinct expression programs among similar cell types cannot be accomplished solely by deterministic regulatory systems, but by the involvement of some type of stochasticity. In the last few years our understanding of these non-deterministic mechanisms is advancing, and this review will provide a brief summary of the current view of stochastic gene expression with focus on olfactory receptor gene choice, the epigenetic underpinnings of which recently began to emerge.
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