Photoacoustic Imaging of COVID-19 Vaccine Site Inflammation of Autoimmune Disease Patients.
Photoacoustic Imaging of COVID-19 Vaccine Site Inflammation of Autoimmune Disease Patients.
复制标题
DOI：
10.3390/s23052789
复制
发表时间：
2023-03-03
期刊：
影响因子：
--
通讯作者：
Gandikota G
中科院分区：
文献类型：
--
作者：
Jo J;Mills D;Dentinger A;Chamberland D;Abdulaziz NM;Wang X;Schiopu E;Gandikota G
根据风湿病诊所的观察，服用免疫抑制（IS）药物的自身免疫性疾病（AD）患者有不同的疫苗部位炎症反应，其研究可能有助于预测疫苗在这一高危人群中的长期疗效。然而，对疫苗部位炎症的定量评估在技术上具有挑战性。在这项分析使用 IS 药物的 AD 患者和正常对照受试者的研究中，我们使用新兴的光声成像 (PAI) 方法和已建立的多普勒超声 (US) 方法对接种 mRNA COVID-19 疫苗 24 小时后疫苗部位的炎症进行成像。共有15名受试者参与其中，其中包括6名IS AD患者和9名正常对照受试者，并对两组结果进行比较。与对照受试者的结果相比，接受 IS 药物治疗的 AD 患者的疫苗部位炎症在统计上显着减少，这表明免疫抑制的 AD 患者在 mRNA 疫苗接种后也会出现局部炎症，但与未免疫抑制的非 AD 个体相比，其临床表现并不明显。 PAI 和 Doppler US 均能够检测 mRNA COVID-19 疫苗引起的局部炎症。基于光学吸收对比的 PAI 在评估和量化疫苗部位软组织空间分布的炎症方面表现出更好的灵敏度。
Based on the observations made in rheumatology clinics, autoimmune disease (AD) patients on immunosuppressive (IS) medications have variable vaccine site inflammation responses, whose study may help predict the long-term efficacy of the vaccine in this at-risk population. However, the quantitative assessment of the inflammation of the vaccine site is technically challenging. In this study analyzing AD patients on IS medications and normal control subjects, we imaged the inflammation of the vaccine site 24 h after mRNA COVID-19 vaccinations were administered using both the emerging photoacoustic imaging (PAI) method and the established Doppler ultrasound (US) method. A total of 15 subjects were involved, including 6 AD patients on IS and 9 normal control subjects, and the results from the two groups were compared. Compared to the results obtained from the control subjects, the AD patients on IS medications showed statistically significant reductions in vaccine site inflammation, indicating that immunosuppressed AD patients also experience local inflammation after mRNA vaccination but not in as clinically apparent of a manner when compared to non-immunosuppressed non-AD individuals. Both PAI and Doppler US were able to detect mRNA COVID-19 vaccine-induced local inflammation. PAI, based on the optical absorption contrast, shows better sensitivity in assessing and quantifying the spatially distributed inflammation in soft tissues at the vaccine site.
登录
查看更多内容
影响因子：
7.9
作者：
Hariri A;Lemaster J;Wang J;Jeevarathinam AS;Chao DL;Jokerst JV
通讯作者：
Jokerst JV
图形处理单元和代码并行优化促进实时光声和超声双模态成像系统
影响因子：
3.5
作者：
Yuan, Jie;Xu, Guan;Liu, Xiaojun
通讯作者：
Liu, Xiaojun
通过基于LED的光声系统对肠炎的成像。
影响因子：
3.5
作者：
Jo J;Xu G;Schiopu E;Chamberland D;Gandikota G;Wang X
通讯作者：
Wang X
影响因子：
7.3
作者：
Burny, Wivine;Callegaro, Andrea;Didierlaurent, Arnaud M.
通讯作者：
Didierlaurent, Arnaud M.
影响因子：
1.3
作者：
Gotthardt, Martin;Bleeker-Rovers, Chantal P.;Oyen, Wim J. G.
通讯作者：
Oyen, Wim J. G.