Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy.
Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy.
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DOI：
10.3389/fimmu.2017.01294
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发表时间：
2017
影响因子：
7.3
通讯作者：
Jones CE
中科院分区：
文献类型：
--
作者：
Wilcox CR;Holder B;Jones CE
新生儿在出生时特别容易受到感染，通过胎盘将免疫球蛋白G(Ig G)从母亲转移到胎儿在生命的头几周提供了至关重要的保护。免疫球蛋白通过与胎盘合体滋养层细胞中的新生儿Fc受体(FcRN)结合而发生转胞作用。随着母体疫苗接种成为保护幼儿的一项日益重要的战略，提高我们对经胎盘移植及其可能影响因素的了解将变得越来越重要，特别是在发病率和死亡率负担最高的低收入国家。这篇综述重点介绍了可能调节胎盘转移的与母体接种相关的因素--免疫球蛋白G亚类、抗体糖基化、母体总免疫球蛋白浓度、母体疾病、婴儿胎龄和出生体重--并概述了关于这些关系的复杂性仍然存在的相互矛盾的证据和问题。此外，抗体-FcRN相互作用的复杂性仍然知之甚少，并描述了可能有助于解决未来研究问题的模型。
At birth, neonates are particularly vulnerable to infection and transplacental transfer of immunoglobulin G (IgG) from mother to fetus provides crucial protection in the first weeks of life. Transcytosis of IgG occurs via binding with the neonatal Fc receptor (FcRn) in the placental synctiotrophoblast. As maternal vaccination becomes an increasingly important strategy for the protection of young infants, improving our understanding of transplacental transfer and the factors that may affect this will become increasingly important, especially in low-income countries where the burden of morbidity and mortality is highest. This review highlights factors of relevance to maternal vaccination that may modulate placental transfer—IgG subclass, glycosylation of antibody, total maternal IgG concentration, maternal disease, infant gestational age, and birthweight—and outlines the conflicting evidence and questions that remain regarding the complexities of these relationships. Furthermore, the intricacies of the Ab–FcRn interaction remain poorly understood and models that may help address future research questions are described.
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影响因子：
3.7
作者：
Dashivets T;Thomann M;Rueger P;Knaupp A;Buchner J;Schlothauer T
通讯作者：
Schlothauer T
影响因子：
6.7
作者：
Bialas KM;Permar SR
通讯作者：
Permar SR
影响因子：
168.9
作者：
Amirthalingam, Gayatri;Andrews, Nick;Ramsay, Mary
通讯作者：
Ramsay, Mary
DOI：
10.1093/cid/ciw559
发表时间：
2016-12-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Amirthalingam G;Campbell H;Ribeiro S;Fry NK;Ramsay M;Miller E;Andrews N
通讯作者：
Andrews N
影响因子：
3.4
作者：
Cavalcante, Rejane S.;Kopelman, Benjamin I.;Costa-Carvalho, Beatriz T.
通讯作者：
Costa-Carvalho, Beatriz T.