Red Blood Cell Membrane-Camouflaged PLGA Nanoparticles Loaded With Basic Fibroblast Growth Factor for Attenuating Sepsis-Induced Cardiac Injury.
Red Blood Cell Membrane-Camouflaged PLGA Nanoparticles Loaded With Basic Fibroblast Growth Factor for Attenuating Sepsis-Induced Cardiac Injury.
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红细胞膜伪装的 PLGA 纳米颗粒负载碱性成纤维细胞生长因子，可减轻脓毒症引起的心脏损伤
DOI：
10.3389/fphar.2022.881320
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发表时间：
2022
影响因子：
5.6
通讯作者：
Lu, Zhongqiu
中科院分区：
文献类型：
--
作者：
Li, Xinze;Hong, Guangliang;Zhao, Guangju;Pei, Hui;Qu, Jie;Chun, Changju;Huang, Zhiwei;Lu, Zhongqiu
关键词：
心脏损伤被认为是脓毒性休克的主要原因，也是脓毒症相关多器官功能障碍的主要组成部分。越来越多的证据表明，调节心肌内氧化应激和炎症反应具有广阔的前景。碱性成纤维细胞生长因子（bFGF）具有抗炎和抗氧化特性。在这项研究中，红细胞膜包裹的聚（丙交酯-共-乙交酯）纳米粒子的合成提供碱性成纤维细胞生长因子（bFGF-RBC/NP）脓毒症诱导的心脏损伤。体外实验表明bFGF-RBC/NP对心肌细胞氧化损伤和炎症损伤具有保护作用。此外，使用来自体内实验的数据验证了bFGF-RBC/NP对心脏损伤的抗氧化和抗炎特性。总的来说，我们的研究使用bFGF治疗脓毒症引起的心脏损伤，并证实bFGF-RBC/NP在治疗心肌功能障碍方面具有治疗益处。本研究为脓毒症心脏损伤的防治提供了新的策略。
Cardiac injury is recognized as a major contributor to septic shock and a major component of the multiple organ dysfunction associated with sepsis. Emerging evidence shows that regulation of the intramyocardial oxidative stress and inflammatory response has a promising prospect. Basic fibroblast growth factor (bFGF) exhibits anti-inflammatory and antioxidant properties. In this study, red blood cell membrane-camouflaged poly (lactide-co-glycolide) nanoparticles were synthesized to deliver bFGF (bFGF-RBC/NP) for sepsis-induced cardiac injury. The in vitro experiments revealed that bFGF-RBC/NP could protect cardiomyocytes from oxidative and inflammatory damage. In addition, the antioxidant and anti-inflammatory properties of bFGF-RBC/NP against cardiac injury were validated using data from in vivo experiments. Collectively, our study used bFGF for the treatment of sepsis-induced cardiac injury and confirmed that bFGF-RBC/NP has therapeutic benefits in the treatment of myocardial dysfunction. This study provides a novel strategy for preventing and treating cardiac injury in sepsis.
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