Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression-Case Report.
Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression-Case Report.
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DOI：
10.3389/fpsyt.2022.815422
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发表时间：
2022
影响因子：
4.7
通讯作者：
Lang UE
中科院分区：
文献类型：
--
作者：
Doll JPK;Vázquez-Castellanos JF;Schaub AC;Schweinfurth N;Kettelhack C;Schneider E;Yamanbaeva G;Mählmann L;Brand S;Beglinger C;Borgwardt S;Raes J;Schmidt A;Lang UE
抑郁症是一种使人衰弱的疾病，至少三分之一的患者对治疗没有反应。近年来，人们观察到肠道微生物群与抑郁症之间的联系，开辟了新的治疗途径。在这里，我们介绍了前两名接受粪便微生物群移植作为附加治疗的重度抑郁症患者。移植后4周，两人的抑郁症状都有所改善。1例患者的效果持续长达8周。胃肠道症状，特别是便秘，反映在微生物组变化中，并在1例患者中得到改善。这份报告表明，FMT在抑郁症中的进一步研究可能值得追求，并增加了意识和安全保证，这两者对于确定FMT在抑郁症治疗中的潜力至关重要。
Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota and depression have been observed in recent years, opening novel treatment avenues. Here, we present the first two patients with major depressive disorder ever treated with fecal microbiota transplantation as add-on therapy. Both improved their depressive symptoms 4 weeks after the transplantation. Effects lasted up to 8 weeks in one patient. Gastrointestinal symptoms, constipation in particular, were reflected in microbiome changes and improved in one patient. This report suggests further FMT studies in depression could be worth pursuing and adds to awareness as well as safety assurance, both crucial in determining the potential of FMT in depression treatment.
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作者：
Chudzik A;Orzyłowska A;Rola R;Stanisz GJ
通讯作者：
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