Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain-Gut-Microbiome Axis.
Probiotics, Prebiotics and Postbiotics on Mitigation of Depression Symptoms: Modulation of the Brain-Gut-Microbiome Axis.
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DOI：
10.3390/biom11071000
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发表时间：
2021-07-07
期刊：
影响因子：
5.5
通讯作者：
Stanisz GJ
中科院分区：
文献类型：
--
作者：
Chudzik A;Orzyłowska A;Rola R;Stanisz GJ
脑-肠-微生物轴是肠道微生物群和中枢神经系统之间的双向通讯途径。随着人们对肠道微生物群及其与大脑相互作用机制的兴趣日益浓厚，益生菌、益生元和后益生菌在预防和治疗抑郁症方面的潜在应用受到了相当大的关注。这篇综述讨论了在临床前和临床试验中关于使用前、前和后生物制剂治疗抑郁症的最新发现。在啮齿动物抑郁症模型中进行的研究表明，其中一些药物抑制炎症，降低皮质酮水平并改变神经代谢物水平，从而导致抑郁症症状减轻。此外，某些临床研究表明，抑郁症患者的情绪改善以及生化参数的变化。
The brain–gut–microbiome axis is a bidirectional communication pathway between the gut microbiota and the central nervous system. The growing interest in the gut microbiota and mechanisms of its interaction with the brain has contributed to the considerable attention given to the potential use of probiotics, prebiotics and postbiotics in the prevention and treatment of depressive disorders. This review discusses the up-to-date findings in preclinical and clinical trials regarding the use of pro-, pre- and postbiotics in depressive disorders. Studies in rodent models of depression show that some of them inhibit inflammation, decrease corticosterone level and change the level of neurometabolites, which consequently lead to mitigation of the symptoms of depression. Moreover, certain clinical studies have indicated improvement in mood as well as changes in biochemical parameters in patients suffering from depressive disorders.
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