Pulmonary hypertensive diseases.
Pulmonary hypertensive diseases.
复制标题
肺动脉高压疾病。
作者：
S. Rounds;S. Rounds;S. Rounds;N. Hill;N. Hill
肺动脉高压可能作为肺血管系统的原发性疾病发生，也可能继发于各种心脏或肺部疾病。肺动脉高压的可逆性取决于可逆性血管收缩和肺血管中不可逆结构变化的相对贡献。尽管最近在肺血管生理学的理解方面取得了进展，但肺动脉高压的发病机制和自然史的知识受到无法无创测量肺动脉压的限制。因此，当患者有肺动脉高压的症状或体征时，疾病通常处于晚期。在低氧性肺疾病的早期，肺动脉高压可能在优化通气和灌注匹配方面具有保护作用。目前尚不清楚肺动脉高压本身在什么时候变得有害。当然，针对潜在的心脏或肺部疾病的治疗是必要的。对重度肺动脉高压合并右心室功能不全进行治疗似乎也是合理的。随着口服有效的肺血管扩张剂的出现，现在可能直接治疗原发性和继发性肺动脉高压。希望通过对血管扩张剂治疗反应的仔细临床评估，我们将了解这些药物是否延长生命并降低原发性和继发性肺动脉高压的发病率。与此同时，关于急性肺血管收缩和持续性肺动脉高压的机制还需要更多的信息。此外，需要一种早期识别轻度高血压患者的方法。（250字处删节）
Pulmonary hypertension may occur as a primary disorder of the pulmonary vasculature or secondary to a variety of cardiac or pulmonary diseases. The reversibility of pulmonary hypertension is dependent on the relative contribution of reversible vasoconstriction and irreversible structural changes in the pulmonary vessels. Despite recent advances in the understanding of pulmonary vascular physiology, knowledge of the pathogenesis and natural history of pulmonary hypertension has been limited by an inability to measure pulmonary arterial pressure noninvasively. Thus, when patients have symptoms or signs of pulmonary hypertension, the disease is usually at an advanced stage. It is possible that early in the course of hypoxic pulmonary disease, pulmonary hypertension may be protective in optimizing matching of ventilation and perfusion. It is not known at what point pulmonary hypertension per se becomes harmful. Certainly, treatment directed at underlying cardiac or pulmonary disease is indicated. It also seems reasonable to treat severe degrees of pulmonary hypertension complicated by right ventricular dysfunction. With the advent of orally effective pulmonary vasodilators, direct treatment of primary and secondary pulmonary hypertension may now be possible. Hopefully, with careful clinical evaluation of the response to vasodilator therapy, we will learn whether these drugs prolong life and reduce morbidity in primary and secondary pulmonary hypertension. In the meantime, much more information is needed regarding the mechanisms of acute pulmonary vasoconstriction and sustained pulmonary hypertension. In addition, a means of early identification of patients with mild hypertension is needed.(ABSTRACT TRUNCATED AT 250 WORDS)
α-萘基硫脲引起的反复肺损伤会导致大鼠右心室肥厚。
DOI：
10.1152/jappl.1984.56.2.388
发表时间：
1984
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
Hill,NS;O'Brien,RF;Rounds,S
通讯作者：
Rounds,S
α-萘基硫脲损伤的大鼠肺部的血管反应性增加。
DOI：
10.1152/jappl.1983.54.6.1693
发表时间：
1983
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
Hill,NS;Rounds,S
通讯作者：
Rounds,S
α-萘基硫脲诱导肺微血管通透性增加。
DOI：
10.1152/jappl.1982.52.5.1316
发表时间：
1982
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
Rutili,G;Kvietys,P;Martin,D;Parker,JC;Taylor,AE
通讯作者：
Taylor,AE