Serum Concentrations of the Endocannabinoid, 2-Arachidonoylglycerol, in the Peri-Trauma Period Are Positively Associated with Chronic Pain Months Later.
Serum Concentrations of the Endocannabinoid, 2-Arachidonoylglycerol, in the Peri-Trauma Period Are Positively Associated with Chronic Pain Months Later.
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DOI：
10.3390/biomedicines10071599
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发表时间：
2022-07-05
期刊：
影响因子：
4.7
通讯作者：
deRoon-Cassini, Terri A.
中科院分区：
文献类型：
--
作者：
Trevino, Colleen M.;Hillard, Cecilia J.;Szabo, Aniko;deRoon-Cassini, Terri A.
Endocannabinoid signaling and the hypothalamic-pituitary-adrenal axis are activated by trauma and both stress systems regulate the transition from acute to chronic pain. This study aimed to develop a model of relationships among circulating concentrations of cortisol and endocannabinoids (eCBs) immediately after traumatic injury and the presence of chronic pain months later. Pain scores and serum concentrations of eCBs and cortisol were measured during hospitalization and 5–10 months later in 147 traumatically injured individuals. Exploratory correlational analyses and path analysis were completed. The study sample was 50% Black and Latino and primarily male (69%); 34% percent endorsed a pain score of 4 or greater at follow-up and were considered to have chronic pain. Path analysis was used to model relationships among eCB, 2-arachidonolyglycerol (2-AG), cortisol, and pain, adjusting for sex and injury severity (ISS). Serum 2-AG concentrations at the time of injury were associated with chronic pain in 3 ways: a highly significant, independent positive predictor; a mediator of the effect of ISS, and through a positive relationship with cortisol concentrations. These data indicate that 2-AG concentrations at the time of an injury are positively associated with chronic pain and suggest excessive activation of endocannabinoid signaling contributes to risk for chronic pain.
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DOI：
10.1523/jneurosci.0496-11.2011
发表时间：
2011-07-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hill MN;McLaughlin RJ;Pan B;Fitzgerald ML;Roberts CJ;Lee TT;Karatsoreos IN;Mackie K;Viau V;Pickel VM;McEwen BS;Liu QS;Gorzalka BB;Hillard CJ
通讯作者：
Hillard CJ
DOI：
10.1097/00005373-197403000-00001
发表时间：
1974-01-01
影响因子：
--
作者：
BAKER, SP;ONEILL, B;LONG, WB
通讯作者：
LONG, WB
影响因子：
1.6
作者：
Kaufmann, I.;Hauer, D.;Schelling, G.
通讯作者：
Schelling, G.
影响因子：
6.8
作者：
deRoon-Cassini TA;Bergner CL;Chesney SA;Schumann NR;Lee TS;Brasel KJ;Hillard CJ
通讯作者：
Hillard CJ
影响因子：
3.7
作者：
Fichna J;Wood JT;Papanastasiou M;Vadivel SK;Oprocha P;Sałaga M;Sobczak M;Mokrowiecka A;Cygankiewicz AI;Zakrzewski PK;Małecka-Panas E;Krajewska WM;Kościelniak P;Makriyannis A;Storr MA
通讯作者：
Storr MA