Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass surgery.
Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass surgery.
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DOI：
10.1177/0148607110381403
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Earthman CP
中科院分区：
文献类型：
--
作者：
Beckman LM;Beckman TR;Sibley SD;Thomas W;Ikramuddin S;Kellogg TA;Ghatei MA;Bloom SR;le Roux CW;Earthman CP
Roux-en-Y胃旁路术（RYGB）可长期减轻体重，其机制尚不清楚。与传统减肥方法相比，瘦素和胃肠道（GI）激素（包括胰高血糖素样肽1（GLP-1）、肽YY（PYY）和饥饿素）的变化可能有助于RYGB的相对成功。本研究评估了RYGB后GI激素和瘦素的变化。该研究还评估了在短期摄入蛋白质或脂肪后，GI激素是否会有所不同。在RYGB之前和RYGB之后长达1年的16名妇女中评估GLP-1、PYY、ghrelin和瘦素。在短期等量蛋白质或脂肪之前和之后多次收集血浆。与基线相比，脂肪饮料（FAT-BEV）组中GLP-1曲线下面积（AUC）在第6周和第1年增加。在FAT-BEV组中，PYY AUC在1年时保持升高。与基线相比，蛋白质饮料（PRO-BEV）组中的Ghrelin AUC在第2周、第6周和第1年降低。在第6周，PRO-BEV组中的Ghrelin AUC低于FAT-BEV组。两组在所有访视时空腹瘦素均下降，并且在1年时FAT-BEV组低于PRO-BEV组。所有GI激素和瘦素较基线的变化均很明显;一些差异在手术后不久就很明显（生长激素释放肽、瘦素），而其他差异则长期维持（GLP-1、PYY、生长激素释放肽、瘦素）。在短期刺激的反应中，蛋白质抑制生长激素释放肽和脂肪有力地刺激GLP-1和PYY。今后在这方面的工作是必要的。
Roux-en-Y gastric bypass (RYGB) imparts long-term weight loss, the mechanisms for which are not well understood. Changes in leptin and gastrointestinal (GI) hormones, including glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and ghrelin, may contribute to the relative success of RYGB compared with conventional weight loss methods. This study evaluated changes in GI hormones and leptin post-RYGB. The study also evaluated whether GI hormones differed after a short-term dose of protein or fat. GLP-1, PYY, ghrelin, and leptin were assessed in 16 women before RYGB and up to 1 year after RYGB. Plasma was collected before and at several times after a short-term equicaloric dose of protein or fat. GLP-1 area under the curve (AUC) increased at week 6 and 1 year in the fat beverage (FAT-BEV) group compared with baseline. PYY AUC remained elevated at 1 year in the FAT-BEV group. Ghrelin AUC decreased at week 2, week 6, and 1 year in the protein beverage (PRO-BEV) group compared with baseline. Ghrelin AUC was lower in the PRO-BEV group compared with the FAT-BEV group at week 6. Fasted leptin decreased at all visits in both groups and was lower in the FAT-BEV group compared with the PRO-BEV group at 1 year. Changes from baseline were evident for all GI hormones and leptin; some differences were evident soon after surgery (ghrelin, leptin), whereas others were maintained long term (GLP-1, PYY, ghrelin, leptin). In response to a short-term stimulus, protein suppressed ghrelin and fat potently stimulated GLP-1 and PYY. Future work in this area is warranted.
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影响因子：
2.9
作者：
Czupryniak, Leszek;Pawlowski, Maciej;Strzelczyk, Janusz
通讯作者：
Strzelczyk, Janusz
影响因子：
5.8
作者：
Bowen, J;Noakes, M;Clifton, PM
通讯作者：
Clifton, PM
影响因子：
24.5
作者：
ADRIAN, TE;BLOOM, SR;BARNES, AJ
通讯作者：
BARNES, AJ
DOI：
10.1016/j.soard.2005.04.002
发表时间：
2005-05-01
期刊：
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
影响因子：
--
作者：
Buchwald, Henry
通讯作者：
Buchwald, Henry
影响因子：
2.9
作者：
Couce, Marta E.;Cottam, Daniel;Burguera, Bartolome
通讯作者：
Burguera, Bartolome