Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously.
Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously.
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同时使用两种药物可增强生长激素和胰岛素样生长因子 I 的合成代谢作用。
DOI：
10.1172/jci116212
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Clemmons,DR
中科院分区：
文献类型：
--
作者：
Kupfer,SR;Underwood,LE;Baxter,RC;Clemmons,DR
生长激素（GH）作为合成代谢剂的使用受到其引起高血糖的倾向以及在某些分解代谢条件下无法逆转氮浪费的限制。在之前的一项比较 GH 和 IGF-I（胰岛素样生长因子 I）合成代谢作用的研究中，我们观察到静脉输注 IGF-I（12 微克/千克理想体重 [IBW]/小时）可减少氮浪费，其程度与按每天 0.05 毫克/千克 IBW 标准剂量皮下注射 GH 相当。然而，IGF-I 有引起低血糖的倾向。在本研究中，我们使用 GH 和 IGF-I 联合治疗（使用与之前研究中相同的剂量）治疗七名热量限制（每天 20 kcal/kg IBW）正常志愿者，并比较其对合成代谢和碳水化合物代谢的影响与单独使用 IGF-I 的治疗。与单独使用 IGF-I（108 +/- 29 mmol/d；P < 0.001）相比，GH/IGF-I 组合引起显着更高的氮滞留（262 +/- 43 mmol/d，平均值 +/- SD）。 GH/IGF-I 治疗导致大量尿钾保留（34 +/- 3 mmol/d，平均值+/- SE；P < 0.001），表明大多数蛋白质积聚发生在肌肉和结缔组织中。与单独的 IGF-I（3.8 +/- 0.8 mmol/L；P < 0.001）相比，GH 减弱了 IGF-I 引起的低血糖，GH/IGF-I 组的低血糖发作次数更少，毛细血管血糖浓度更高（4.3 +/- 1.0 mmol/L，平均值 +/- SD）。与 GH/IGF-I 组合（2,280 +/- 612 pmol/升；P < 0.001）相比，IGF-I 导致 C 肽显着下降（1,165 +/- 341 pmol/升；平均值 +/- SD），表明后一种方案可维持正常的碳水化合物代谢。与仅 IGF-I 治疗（1,092 +/- 503 微克/升；P < 0.001）相比，GH/IGF-I 产生更高的血清 IGF-I 浓度（1,854 +/- 708 微克/升；平均值 +/- SD）。这一观察结果与 GH/IGF-I 治疗时 IGF 结合蛋白 3 和酸不稳定亚基浓度增加以及单独 IGF-I 浓度降低有关。这些结果表明，GH 和 IGF-I 治疗的组合比单独的 IGF-I 或 GH 的合成代谢显着增强。 GH/IGF-I 治疗还可减轻单独由 IGF-I 引起的低血糖。 GH/IGF-I 治疗可能在与分解代谢相关的疾病中具有重要的应用。
The use of growth hormone (GH) as an anabolic agent is limited by its tendency to cause hyperglycemia and by its inability to reverse nitrogen wasting in some catabolic conditions. In a previous study comparing the anabolic actions of GH and IGF-I (insulin-like growth factor I), we observed that intravenous infusions of IGF-I (12 micrograms/kg ideal body wt [IBW]/h) attenuated nitrogen wasting to a degree comparable to GH given subcutaneously at a standard dose of 0.05 mg/kg IBW per d. IGF-I, however, had a tendency to cause hypoglycemia. In the present study, we treated seven calorically restricted (20 kcal/kg IBW per d) normal volunteers with a combination of GH and IGF-I (using the same doses as in the previous study) and compared its effects on anabolism and carbohydrate metabolism to treatment with IGF-I alone. The GH/IGF-I combination caused significantly greater nitrogen retention (262 +/- 43 mmol/d, mean +/- SD) compared to IGF-I alone (108 +/- 29 mmol/d; P < 0.001). GH/IGF-I treatment resulted in substantial urinary potassium conservation (34 +/- 3 mmol/d, mean +/- SE; P < 0.001), suggesting that most protein accretion occurred in muscle and connective tissue. GH attenuated the hypoglycemia induced by IGF-I as indicated by fewer hypoglycemic episodes and higher capillary blood glucose concentrations on GH/IGF-I (4.3 +/- 1.0 mmol/liter, mean +/- SD) compared to IGF-I alone (3.8 +/- 0.8 mmol/liter; P < 0.001). IGF-I caused a marked decline in C-peptide (1,165 +/- 341 pmol/liter; mean +/- SD) compared to the GH/IGF-I combination (2,280 +/- 612 pmol/liter; P < 0.001), suggesting maintenance of normal carbohydrate metabolism with the latter regimen. GH/IGF-I produced higher serum IGF-I concentrations (1,854 +/- 708 micrograms/liter; mean +/- SD) compared to IGF-I only treatment (1,092 +/- 503 micrograms/liter; P < 0.001). This observation was associated with increased concentrations of IGF binding protein 3 and acid-labile subunit on GH/IGF-I treatment and decreased concentrations on IGF-I alone. These results suggest that the combination of GH and IGF-I treatment is substantially more anabolic than either IGF-I or GH alone. GH/IGF-I treatment also attenuates the hypoglycemia caused by IGF-I alone. GH/IGF-I treatment could have important applications in diseases associated with catabolism.
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用人类生长激素和低热量静脉喂养实现正氮平衡。
影响因子：
3.8
作者：
Manson,JM;Wilmore,DW
通讯作者：
Wilmore,DW
通过在人体中输注重组胰岛素样生长因子-I 来逆转饮食诱导的分解代谢。
DOI：
10.1210/jcem.75.1.1619015
发表时间：
1992
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Clemmons,DR;Smith-Banks,A;Underwood,LE
通讯作者：
Underwood,LE
影响因子：
9.8
作者：
HO, KY;WEISSBERGER, AJ
通讯作者：
WEISSBERGER, AJ
亮氨酸、精氨酸和肾上腺素无法在体外改变血浆胰岛素水平
影响因子：
2.2
作者：
S. Voina;L. Underwood;J. J. Wyk
通讯作者：
J. J. Wyk
影响因子：
15.9
作者：
HORBER, FF;HAYMOND, MW
通讯作者：
HAYMOND, MW