Theranostic oxygen delivery using ultrasound and microbubbles.
Theranostic oxygen delivery using ultrasound and microbubbles.
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DOI：
10.7150/thno.4410
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发表时间：
2012
期刊：
影响因子：
12.4
通讯作者：
Dayton PA
中科院分区：
文献类型：
--
作者：
Kwan JJ;Kaya M;Borden MA;Dayton PA
自20世纪60年代S以来，克服肿瘤缺氧的方法一直是临床研究的主题，但这些研究尚未找到被广泛接受的治疗方法。近一个世纪以来，人们已经知道缺氧细胞比有氧细胞对放射治疗的抵抗力更强，而肿瘤缺氧是导致肿瘤对放射治疗和几种细胞毒剂产生抵抗力的主要因素。本文介绍了超声结合载氧微泡作为局部增氧方法的应用。微泡也可以通过超声波成像，从而为图像引导氧气输送提供了机会。气体扩散和微泡气体交换的模拟表明，少量(低至5%)的低溶解度渗透气体可以显著提高微泡的持久性，从而提高载氧微泡的产率和稳定性。模拟还表明，脂壳可以被设计成长链脂类，以增加体内转运过程中的氧气有效负荷。实验结果表明，应用超声波破坏微泡可以显著提高局部氧气的释放。我们建议将这项技术应用于超声图像引导下将氧气直接释放到低氧组织，如肿瘤部位，以加强放射治疗。
Means to overcome tumor hypoxia have been the subject of clinical investigations since the 1960's; however these studies have yet to find a treatment which is widely accepted. It has been known for nearly a century that hypoxic cells are more resistant to radiotherapy than aerobic cells, and tumor hypoxia is a major factor leading to the resistance of tumors to radiation treatment as well as several cytotoxic agents. In this manuscript, the application of ultrasound combined with oxygen-carrier microbubbles is demonstrated as a method to locally increase dissolved oxygen. Microbubbles can also be imaged by ultrasound, thus providing the opportunity for image-guided oxygen delivery. Simulations of gas diffusion and microbubble gas exchange show that small amounts (down to 5 vol%) of a low-solubility osmotic gas can substantially increase microbubble persistence and therefore production rates and stability of oxygen-carrier microbubbles. Simulations also indicate that the lipid shell can be engineered with long-chain lipids to increase oxygen payload during in vivo transit. Experimental results demonstrate that the application of ultrasound to destroy the microbubbles significantly enhances the local oxygen release. We propose this technology as an application for ultrasound image-guided release of oxygen directly to hypoxic tissue, such as tumor sites to enhance radiotherapy.
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影响因子：
3.5
作者：
Chomas, JE;Dayton, P;Ferrara, K
通讯作者：
Ferrara, K
影响因子：
--
作者：
Mullin, Lee;Gessner, Ryan;Kwan, James;Kaya, Mehmet;Borden, Mark A.;Dayton, Paul A.
通讯作者：
Dayton, Paul A.
影响因子：
5.7
作者：
Nordsmark, M;Bentzen, SM;Overgaard, J
通讯作者：
Overgaard, J
影响因子：
3.9
作者：
Borden, MA;Martinez, GV;Ferrara, KW
通讯作者：
Ferrara, KW
DOI：
10.1080/10731190600974939
发表时间：
2007-01-01
期刊：
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
影响因子：
--
作者：
Gerber, Frederic;Waton, Gilles;Vandamme, Thierry F.
通讯作者：
Vandamme, Thierry F.