HPA-axis reactivity interacts with stage of pubertal development to predict the onset of depression.
HPA-axis reactivity interacts with stage of pubertal development to predict the onset of depression.
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DOI：
10.1016/j.psyneuen.2015.02.004
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发表时间：
2015-05
影响因子：
3.7
通讯作者：
Gotlib, Ian H.
中科院分区：
文献类型：
--
作者：
Colich, Natalie L.;Kircanski, Katharina;Foland-Ross, Lara C.;Gotlib, Ian H.
儿童和青少年时期皮质醇分泌水平的升高和降低都与随后发生的重度抑郁症（MDD）有关。这些混杂的发现可能是由于hpa轴功能的发育变化，这在以前的风险背景下没有被评估过。因此，在本研究中，我们研究了青春期发育是否会调节皮质醇分泌对MDD后续发展的影响。89名年龄在9-15岁之间、从未患过抑郁症的女孩完成了一项实验室压力任务，其中许多人由于母亲有抑郁症病史而处于患抑郁症的高风险。为了指数皮质醇的反应性，在基线和应激源发生后15分钟收集唾液皮质醇样本。女孩的青春期发展水平是用坦纳分期来衡量的。所有参与者都被跟踪到18岁，以评估重度抑郁症的后续发展。青春期调节皮质醇应激反应对重度抑郁症发展的影响。具体来说，青春期发育较早的女孩（Tanner期≤2）的皮质醇低反应性可预测MDD的发病，而青春期发育较晚的女孩（Tanner期≥3.5）的皮质醇高反应性可预测MDD的发病。这些发现表明，女孩的皮质醇应激反应预示着随后的重度抑郁症的发作，进一步说，这种影响的性质取决于女孩的青春期发育水平。本文对研究结果进行了讨论，并对未来的研究方向进行了展望。
Both elevated and blunted levels of cortisol secretion during childhood and adolescence have been linked to the subsequent onset of Major Depressive Disorder (MDD). These mixed findings may be due to developmental changes in HPA-axis functioning, which have not been previously assessed in the context of risk. In the present study, therefore, we examined whether pubertal development moderated the influence of cortisol secretion on the subsequent development of MDD. Eighty-nine never-disordered girls ages 9-15 years, many of whom were at high risk for depression by virtue of having a maternal history of the disorder, completed a laboratory stress task. To index cortisol reactivity, salivary cortisol samples were collected at baseline and 15 minutes following the onset of the stressor. Girls' levels of pubertal development were measured using Tanner staging. All participants were followed through age 18 in order to assess the subsequent development of MDD. Pubertal stage moderated the effects of cortisol stress reactivity on the development of MDD. Specifically, the onset of MDD was predicted by cortisol hyporeactivity in girls who were earlier in pubertal development (Tanner stage ≤ 2), but by cortisol hyperreactivity in girls who were later in pubertal development (Tanner stage ≥ 3.5). These findings demonstrate that girls' cortisol stress reactivity predicts the subsequent onset of MDD, and further, that the nature of this effect depends on the girls' level of pubertal development. Results are discussed in the context of clarifying previous findings, and directions for future research are offered.
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影响因子：
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作者：
Luby, JL;Heffelfinger, A;Spitznagel, E
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