Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence.
Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence.
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DOI：
10.1016/j.psyneuen.2009.12.007
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发表时间：
2010-07
影响因子：
3.7
通讯作者：
Griffith, James W.
中科院分区：
文献类型：
--
作者：
Adam, Emma K.;Doane, Leah D.;Zinbarg, Richard E.;Mineka, Susan;Craske, Michelle G.;Griffith, James W.
关键词：
压力敏感激素皮质醇的水平在醒来后的前30-40分钟内急剧增加，这种效应被称为皮质醇觉醒反应（CAR）。有相当多的横断面证据表明，心理社会压力与CAR增加有关，并且已经发现CAR在存在压力相关疾病（包括重度抑郁症（MDD））的情况下发生改变。到目前为止，还没有前瞻性纵向研究检查CAR的个体差异是否是MDD的发病前风险因素。在230名晚期青少年的样本中，根据CAR以及一年前收集的基础皮质醇功能的其他指标预测MDD的临床诊断，包括：清醒皮质醇水平，睡前皮质醇水平，CAR的大小，平均皮质醇，以及清醒日的昼夜皮质醇节律的斜率。年龄和性别，健康和健康行为，基线神经质，暴露于压力生活事件以及过去的情绪和焦虑症发作被纳入作为协变量，以帮助确保影响归因于CAR而不是相关变量。基线CAR越高，随访时发生MDD的风险越高，即使排除基线MDD患者也是如此。没有其他基线皮质醇指标是MDD的重要前瞻性预测因子。总之，CAR是年轻人发生MDD的一个重要的前瞻性风险因素，为CAR升高可能在重度抑郁症的病因学中发挥作用的可能性提供了一些支持。
Levels of the stress-sensitive hormone cortisol increase dramatically in the first 30-40 minutes after waking, an effect known as the cortisol awakening response (CAR). There is considerable cross-sectional evidence that psychosocial stress is associated with an increased CAR, and the CAR has been found to be altered in the presence of stress-related diseases, including Major Depressive Disorder (MDD). To date, no prospective longitudinal studies have examined whether individual differences in the CAR serve as a premorbid risk factor for MDD. In a sample of 230 late adolescents, clinical diagnoses of MDD were predicted from the CAR as well as other indicators of basal cortisol functioning gathered one year earlier, including: waking cortisol levels, bedtime cortisol levels, the size of the CAR, average cortisol, and the slope of the diurnal cortisol rhythm across the waking day. Age and gender, health and health behaviors, baseline neuroticism, exposure to stressful life events and past episodes of mood and anxiety disorders were included as covariates, to help ensure effects are attributable to the CAR rather than related variables. A higher baseline CAR was associated with a significantly increased risk of developing MDD by follow-up, even when excluding individuals with baseline MDD. No other baseline cortisol measures were significant prospective predictors of MDD. In summary, the CAR is a significant prospective risk factor for the development of MDD in young adults, providing some support for the possibility that a heightened CAR may play a role in the etiology of Major Depressive Disorder.
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DOI：
10.1073/pnas.0605053103
发表时间：
2006-11-07
影响因子：
11.1
作者：
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通讯作者：
Cacioppo, John T.
影响因子：
7.6
作者：
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通讯作者：
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影响因子：
10.6
作者：
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通讯作者：
Murray, L
影响因子：
17.7
作者：
Bremner, JD;Narayan, M;Charney, DS
通讯作者：
Charney, DS
影响因子：
--
作者：
Costello, EJ;Mustillo, S;Angold, A
通讯作者：
Angold, A