Retinal capillary rarefaction is associated with arterial and kidney damage in hypertension.
Retinal capillary rarefaction is associated with arterial and kidney damage in hypertension.
复制标题
视网膜毛细血管稀疏与高血压中的动脉和肾脏损伤有关。
DOI：
10.1038/s41598-020-79594-3
复制
发表时间：
2021-01-13
影响因子：
4.6
通讯作者：
Schlaich MP
中科院分区：
文献类型：
--
作者：
Frost S;Nolde JM;Chan J;Joyson A;Gregory C;Carnagarin R;Herat LY;Matthews VB;Robinson L;Vignarajan J;Prentice D;Kanagasingam Y;Schlaich MP
微血管病变和血管稀疏是高血压的重要病理标志。视网膜独特地允许对微血管进行直接、非侵入性的研究。最近发展的光学相干断层扫描血管造影术现在允许调查的罚款视网膜毛细血管，这可能会提供一个上级标记的整体血管损伤。这是一项前瞻性横断面研究，收集了150名高血压成年人300只正常眼睛的视网膜毛细血管密度数据，并调查与其他器官损伤标志物的可能关联。参与者的平均年龄为54岁，男性比例（85; 57%）高于女性。多变量、混杂因素校正的线性回归显示，视网膜旁毛细血管稀疏与脉搏波速度（β = − 0.4，P = 0.04）、对数白蛋白/肌酐比值（β = − 0.71，P = 0.003）增加和估计肾小球滤过率降低（β = 0.04，P = 0.02）相关。全像血管密度也有相当的显著相关性，而中央凹血管密度仅与脉搏波速度和估计的肾小球滤过率有显著相关性。我们的研究结果表明，视网膜毛细血管稀疏与动脉硬化和肾功能受损。视网膜毛细血管稀疏可能是一个有用的和简单的测试，以评估高血压对微血管系统的综合负担，无论目前的血压水平。
Microvascular disease and rarefaction are key pathological hallmarks of hypertension. The retina uniquely allows direct, non-invasive investigation of the microvasculature. Recently developed optical coherence tomography angiography now allows investigation of the fine retinal capillaries, which may provide a superior marker of overall vascular damage. This was a prospective cross-sectional study to collect retinal capillary density data on 300 normal eyes from 150 hypertensive adults, and to investigate possible associations with other organ damage markers. The average age of participants was 54 years and there was a greater proportion of males (85; 57%) than females. Multivariate, confounder adjusted linear regression showed that retinal capillary rarefaction in the parafovea was associated with increased pulse wave velocity (β = − 0.4, P = 0.04), log-albumin/creatinine ratio (β = − 0.71, P = 0.003), and with reduced estimated glomerular filtration rate (β = 0.04, P = 0.02). Comparable significant associations were also found for whole-image vascular-density, for foveal vascular-density significant associations were found with pulse wave velocity and estimated glomerular filtration rate only. Our results indicate that retinal capillary rarefaction is associated with arterial stiffness and impaired kidney function. Retinal capillary rarefaction may represent a useful and simple test to assess the integrated burden of hypertension on the microvasculature irrespective of current blood pressure levels.
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影响因子：
11.2
作者：
Cheung, Ning;Liew, Gerald;Wong, Tien Y.
通讯作者：
Wong, Tien Y.
影响因子：
9.9
作者：
Doubal, F. N.;MacGillivray, T. J.;Wardlaw, J. M.
通讯作者：
Wardlaw, J. M.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
6.1
作者：
Schwartz, MM;Lewis, EJ;Batlle, D
通讯作者：
Batlle, D
影响因子：
3.7
作者：
Jumar A;Harazny JM;Ott C;Friedrich S;Kistner I;Striepe K;Schmieder RE
通讯作者：
Schmieder RE