Multifunctional gold nanostar conjugates for tumor imaging and combined photothermal and chemo-therapy.
Multifunctional gold nanostar conjugates for tumor imaging and combined photothermal and chemo-therapy.
复制标题
用于肿瘤成像和光热化疗联合治疗的多功能金纳米星缀合物
作者：
Chen H;Zhang X;Dai S;Ma Y;Cui S;Achilefu S;Gu Y
将均一的金纳米星（Au NS）分别与环状RGD（cRGD）、近红外（NIR）荧光探针（MPA）或抗癌药物（DOX）偶联，得到多功能纳米构建物Au-cRGD-MPA和Au-cRGD-DOX。NIR造影剂Au-cRGD-MPA显示出具有低细胞毒性。使用肿瘤细胞和荷瘤小鼠，这些成像纳米颗粒表现出有利的肿瘤靶向能力，通过RGD肽结合到其在肿瘤细胞上的过表达受体介导。多治疗类似物Au-cRGD-DOX将靶向肿瘤、化疗和光热治疗整合到一个系统中。在不同的肿瘤细胞系和体内使用S180荷瘤小鼠模型证明了光热疗法和化学疗法的协同作用。MDA-MB-231细胞在与Au-cRGD-DOX孵育并用NIR光照射后的存活率仅为40%。尾静脉和肿瘤内注射均显示Au-cRGD-DOX处理的小鼠表现出最慢的肿瘤增加。这些结果表明，多功能纳米构建物是一种很有前途的肿瘤靶向治疗组合治疗剂，具有提高抗癌治疗效果的潜力。
Uniform gold nanostars (Au NS) were conjugated with cyclic RGD (cRGD) and near infrared (NIR) fluorescence probe (MPA) or anti-cancer drug (DOX) to obtain multi-functional nanoconstructs, Au-cRGD-MPA and Au-cRGD-DOX respectively. The NIR contrast agent Au-cRGD-MPA was shown to have low cytotoxicity. Using tumor cells and tumor bearing mice, these imaging nanoparticles demonstrated favorable tumor-targeting capability mediated by RGD peptide binding to its over-expressed receptor on the tumor cells. The multi-therapeutic analogue, Au-cRGD-DOX, integrates targeting tumor, chemotherapy and photo-thermotherapy into a single system. The synergistic effect of photo-thermal therapy and chemotherapy was demonstrated in different tumor cell lines and in vivo using S180 tumor-bearing mouse models. The viability of MDA-MB-231 cells was only 40 % after incubation with Au-cRGD-DOX and irradiation with NIR light. Both tail vein and intratumoral injections showed Au-cRGD-DOX treated mice exhibiting the slowest tumor increase. These results indicate that the multifunctional nanoconstruct is a promising combined therapeutic agent for tumor-targeting treatment, with the potential to enhance the anti-cancer treatment outcomes.
登录
查看更多内容
影响因子：
17.1
作者：
Jang, Boseung;Park, Jin-Young;Choi, Yongdoo
通讯作者：
Choi, Yongdoo
影响因子：
13.3
作者：
Choi, Jihye;Yang, Jaemoon;Haam, Seungjoo
通讯作者：
Haam, Seungjoo
影响因子：
10.8
作者：
Hao, Feng;Nehl, Colleen L.;Nordlander, Peter
通讯作者：
Nordlander, Peter
影响因子：
17.1
作者：
Huang X;Peng X;Wang Y;Wang Y;Shin DM;El-Sayed MA;Nie S
通讯作者：
Nie S
影响因子：
10.8
作者：
Dulkeith, E;Ringler, M;Parak, WJ
通讯作者：
Parak, WJ