G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasis.
G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasis.
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DOI：
10.1016/j.yfrne.2011.07.002
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发表时间：
2012-01
影响因子：
7.4
通讯作者：
Lolait SJ
中科院分区：
文献类型：
--
作者：
Hazell GG;Hindmarch CC;Pope GR;Roper JA;Lightman SL;Murphy D;O'Carroll AM;Lolait SJ
下丘脑室旁核和视上核是体内平衡的调节器。超过100个G蛋白偶联受体在每个细胞核中表达。受体具有多种功能，包括调节神经肽的合成和释放。大约20-30%的受体是“孤儿”，其内源性配体和功能未知。G蛋白偶联受体（GPCR）是哺乳动物基因组中最大的跨膜受体家族。它们被许多不同的配体激活，这些配体引起快速的细胞内反应以调节细胞功能。不出所料，大部分治疗剂靶向这些受体。下丘脑室旁核（PVN）和视上核（SON）是调节体内平衡的重要介质。PVN/SON活性的许多调节剂，包括神经递质和激素，通过GPCR起作用-事实上，在PVN或SON中已经检测到超过100种非化学感受性GPCR。本文综述了GPCR在PVN/SON中的表达，包括最近转录组学研究的数据，这些研究可能扩大GPCR在这些下丘脑核中可能具有功能作用的库。我们还介绍了PVN/SON中GPCR的调节和已知作用的一些方面，这些方面可能由“孤儿”GPCR的活性补充。
► The paraventricular and supraoptic nuclei of the hypothalamus are regulators of homeostasis. ► Over one hundred G protein-coupled receptors are expressed in each of these nuclei. ► The receptors have many functions including modulating neuropeptide synthesis and release. ► 20–30% of the receptors are ‘orphans’ whose endogenous ligand and function is unknown. G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors in the mammalian genome. They are activated by a multitude of different ligands that elicit rapid intracellular responses to regulate cell function. Unsurprisingly, a large proportion of therapeutic agents target these receptors. The paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus are important mediators in homeostatic control. Many modulators of PVN/SON activity, including neurotransmitters and hormones act via GPCRs – in fact over 100 non-chemosensory GPCRs have been detected in either the PVN or SON. This review provides a comprehensive summary of the expression of GPCRs within the PVN/SON, including data from recent transcriptomic studies that potentially expand the repertoire of GPCRs that may have functional roles in these hypothalamic nuclei. We also present some aspects of the regulation and known roles of GPCRs in PVN/SON, which are likely complemented by the activity of ‘orphan’ GPCRs.
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影响因子：
14.8
作者：
Albizu L;Cottet M;Kralikova M;Stoev S;Seyer R;Brabet I;Roux T;Bazin H;Bourrier E;Lamarque L;Breton C;Rives ML;Newman A;Javitch J;Trinquet E;Manning M;Pin JP;Mouillac B;Durroux T
通讯作者：
Durroux T
影响因子：
3.2
作者：
Boudaba, C;Di, S;Tasker, JG
通讯作者：
Tasker, JG
影响因子：
4.8
作者：
Bealer, SL;Crowley, WR
通讯作者：
Crowley, WR
影响因子：
5.5
作者：
Boudaba, C;Linn, DM;Tasker, JG
通讯作者：
Tasker, JG
影响因子：
3.3
作者：
Becker, J. A. J.;Befort, K.;Blad, C.;Filliol, D.;Ghate, A.;Dembele, D.;Thibalilv, C.;Koch, M.;Muller, J.;Lardenois, A.;Poch, O.;Kieffer, B. L.
通讯作者：
Kieffer, B. L.