A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice.
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DOI：
10.1155/2015/675149
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发表时间：
2015
影响因子：
--
通讯作者：
He RR
中科院分区：
文献类型：
--
作者：
Cai Y;Li YF;Tang LP;Tsoi B;Chen M;Chen H;Chen XM;Tan RR;Kurihara H;He RR
众所周知，维生素C可以预防流感感染，但对其机制知之甚少。本研究旨在探讨维生素C对流感病毒致应激小鼠肺炎的影响及其可能机制。结果表明，束缚应激显著增加了A/FM/1/47（H1N1）病毒感染引起的小鼠死亡率和肺炎严重程度，口服维生素C（125和250 mg/kg）可减轻这种情况。此外，维生素C给药显著降低了易感基因的表达，包括线粒体抗病毒信号传导（MAVS）和干扰素调节因子3（IRF 3），并增加了NF-κB的表达。这些协同工作以诱导I型干扰素（IFN）并引发先天性抗病毒应答，作为RIG-I介导的信号转导途径中的关键因子。进一步发现维生素C的上述作用与调节肾上腺类固醇羟化酶抑制皮质醇过量合成有关。总之，维生素C对流感病毒引起的肺炎的保护作用可能与其抑制CORT合成有关，这降低了限制应激小鼠对流感病毒感染的易感性。这些发现为维生素C对限制应激小鼠流感病毒诱导的肺炎的影响提供了新的机制。
It is well known that vitamin C could protect against influenza infection, but little is known about the mechanisms. This study aimed to investigate the influence and possible mechanisms of vitamin C on pneumonia induced by influenza virus in stressed mice. Results showed that restraint stress significantly increased the mortality and the severity of pneumonia in mice caused by A/FM/1/47(H1N1) virus infection, which was attenuated by oral administration of vitamin C (125 and 250 mg/kg). Moreover, vitamin C administration significantly decreased expression of susceptibility genes, including mitochondrial antiviral signaling (MAVS) and interferon regulatory factor 3 (IRF3), and increased expression of NF-κB. These work in conjunction to induce type I interferons (IFNs) and elicit innate antiviral response as key factors in RIG-I-mediated signal transduction pathway. The above effects of vitamin C were further found to relate with inhibition of excess CORT synthesis by regulating steroid hydroxylating enzymes in adrenal gland. In conclusion, the protective effects of vitamin C on influenza virus-caused pneumonia might be related to its inhibition of CORT synthesis, which reduces the susceptibility to influenza viral infection in restraint-stressed mice. These findings provide a new mechanism for the effects of vitamin C on influenza virus-induced pneumonia in restraint-stressed mice.
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DOI：
10.1046/j.1467-2494.1998.171747.x
发表时间：
1998-06-01
影响因子：
2.3
作者：
Boyera, N.;Galey, I.;Bernard, B. A.
通讯作者：
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影响因子：
3.7
作者：
Li YF;He RR;Tsoi B;Li XD;Li WX;Abe K;Kurihara H
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Kurihara H
影响因子：
13.6
作者：
Di Cornite, Gabriele;Sabbadini, Maria Grazia;Manfredi, Angelo A.
通讯作者：
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影响因子：
5.4
作者：
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通讯作者：
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影响因子：
4.7
作者：
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