Regulation of brown adipocyte metabolism by myostatin/follistatin signaling.
Regulation of brown adipocyte metabolism by myostatin/follistatin signaling.
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DOI：
10.3389/fcell.2014.00060
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发表时间：
2014
影响因子：
5.5
通讯作者：
Pervin S
中科院分区：
文献类型：
--
作者：
Singh R;Braga M;Pervin S
肥胖源于细胞生物能量学的扰动，当能量摄取超过能量消耗时，肥胖症是2型糖尿病、血脂异常、心血管疾病、癌症和其他疾病发展的主要危险因素。棕色脂肪组织(BAT)长期以来一直被认为是以热量的形式耗散能量，并有助于能量消耗，但它的存在及其在成人人体生理学中的生理作用多年来一直受到质疑。最近在成人体内发现的代谢活跃的棕色脂肪储存库已经彻底改变了目前肥胖相关疾病的治疗方法。白色脂肪组织(WAT)和BAT之间的平衡影响全身能量平衡，被广泛认为是肥胖和相关代谢性疾病发生的关键决定因素。转化生长因子-β(转化生长因子-β)超家族成员通过调节棕色脂肪细胞的特性，在调节整体能量平衡方面发挥重要作用。β/Smad3/Mst信号通路的失活促进白色脂肪细胞的褐变，增加线粒体的生物合成，保护小鼠免受饮食诱导的肥胖的影响，提示有必要开发一类新型的转化生长因子-β/Mst拮抗剂来治疗肥胖和相关的代谢性疾病。我们最近描述了卵泡抑素(Fst)在棕色脂肪分化和细胞代谢调节中的重要作用，Fst是一种已知结合和拮抗MST作用的可溶性糖蛋白。在这里，我们重点介绍了使用不同的体外和体内模型进行的各种研究，以支持靶向转化生长因子-β/MST信号转导增强棕色脂肪细胞的功能和调节能量平衡，减少胰岛素抵抗，并抑制肥胖和糖尿病的发展。
Obesity develops from perturbations of cellular bioenergetics, when energy uptake exceeds energy expenditure, and represents a major risk factor for the development of type 2 diabetes, dyslipidemia, cardiovascular disease, cancer, and other conditions. Brown adipose tissue (BAT) has long been known to dissipate energy as heat and contribute to energy expenditure, but its presence and physiological role in adult human physiology has been questioned for years. Recent demonstrations of metabolically active brown fat depots in adult humans have revolutionized current therapeutic approaches for obesity-related diseases. The balance between white adipose tissue (WAT) and BAT affects the systemic energy balance and is widely believed to be the key determinant in the development of obesity and related metabolic diseases. Members of the transforming growth factor-beta (TGF-β) superfamily play an important role in regulating overall energy homeostasis by modulation of brown adipocyte characteristics. Inactivation of TGF-β/Smad3/myostatin (Mst) signaling promotes browning of white adipocytes, increases mitochondrial biogenesis and protects mice from diet-induced obesity, suggesting the need for development of a novel class of TGF-β/Mst antagonists for the treatment of obesity and related metabolic diseases. We recently described an important role of follistatin (Fst), a soluble glycoprotein that is known to bind and antagonize Mst actions, during brown fat differentiation and the regulation of cellular metabolism. Here we highlight various investigations performed using different in vitro and in vivo models to support the contention that targeting TGF-β/Mst signaling enhances brown adipocyte functions and regulates energy balance, reducing insulin resistance, and curbing the development of obesity and diabetes.
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影响因子：
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作者：
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通讯作者：
Farmer SR
DOI：
10.1152/ajpendo.00656.2010
发表时间：
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影响因子：
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作者：
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DOI：
10.1016/j.biocel.2011.11.004
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影响因子：
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作者：
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