Human lung development: recent progress and new challenges.
Human lung development: recent progress and new challenges.
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DOI：
10.1242/dev.163485
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发表时间：
2018-08-15
期刊：
影响因子：
--
通讯作者：
Rawlins EL
中科院分区：
文献类型：
--
作者：
Nikolić MZ;Sun D;Rawlins EL
最近的研究揭示了人类和小鼠肺发育之间的生物学显著差异，并报道了允许对人类肺模型进行实验操作的新的体外系统。同时，新出现的临床数据表明，一些成人肺部疾病的起源是在胚胎发育和儿童时期发现的。这些研究主题的融合促进了对人类肺发育生物学的兴趣的复苏。在这篇综述中，我们讨论了我们目前对人类肺发育的理解，这一理解受到小鼠研究的深刻影响，最近，通过使用体外人类肺发育模型和人类胎儿肺组织RNA测序的实验。总之，这些方法有助于揭示人类肺部发育和疾病的潜在机制，并可能有助于为新疗法铺平道路。总结：本综述介绍了最近的技术进步如何揭示人类肺部发育和疾病的机制，并概述了该领域未来的挑战。
Recent studies have revealed biologically significant differences between human and mouse lung development, and have reported new in vitro systems that allow experimental manipulation of human lung models. At the same time, emerging clinical data suggest that the origins of some adult lung diseases are found in embryonic development and childhood. The convergence of these research themes has fuelled a resurgence of interest in human lung developmental biology. In this Review, we discuss our current understanding of human lung development, which has been profoundly influenced by studies in mice and, more recently, by experiments using in vitro human lung developmental models and RNA sequencing of human foetal lung tissue. Together, these approaches are helping to shed light on the mechanisms underlying human lung development and disease, and may help pave the way for new therapies. Summary: This Review describes how recent technological advances have shed light on the mechanisms underlying human lung development and disease, and outlines the future challenges in this field.
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影响因子：
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DOI：
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发表时间：
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