The critical chemical and mechanical regulation of folic acid on neural engineering.
The critical chemical and mechanical regulation of folic acid on neural engineering.
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DOI：
10.1016/j.biomaterials.2018.03.059
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发表时间：
2018-09
期刊：
影响因子：
14
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Kim GB;Chen Y;Kang W;Guo J;Payne R;Li H;Wei Q;Baker J;Dong C;Zhang S;Wong PK;Rizk EB;Yan J;Yang J
自1998年美国食品和药物管理局推出以来，在谷物产品中补充叶酸的规定已将美国神经管缺陷的发生率降低了三分之一。然而，使用叶酸用于外周神经工程和神经系统疾病的优点和可能的作用机制仍然很难理解。在本文中，叶酸被描述为一种廉价且多功能的生态位组分，其调节神经系统中不同细胞的行为。调节的多种益处包括：1）在神经胶质细胞上产生趋化反应，2）诱导神经营养因子释放，和3）刺激PC-12细胞系统的神经元分化。叶酸还首次被证明可以增强PC-12细胞中的细胞力生成和整体甲基化，从而使生物力学和生物化学途径能够调节神经元分化。在体内评价这些发现以用于临床转化。我们的研究结果表明，叶酸-神经引导导管作为一种低成本的现成产品，可以提供显着的好处，达到与自体移植物在大的坐骨神经缺损中看到的功能恢复。因此，叶酸作为神经工程、再生医学、医疗修复和药物递送的关键和方便的治疗干预具有巨大的潜力。
The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of action of using folic acid for peripheral nerve engineering and neurological diseases still remain largely elusive. Herein, folic acid is described as an inexpensive and multifunctional niche component that modulates behaviors in different cells in the nervous system. The multiple benefits of modulation include: 1) generating chemotactic responses on glial cells, 2) inducing neurotrophin release, and 3) stimulating neuronal differentiation of a PC-12 cell system. For the first time, folic acid is also shown to enhance cellular force generation and global methylation in the PC-12 cells, thereby enabling both biomechanical and biochemical pathways to regulate neuron differentiation. These findings are evaluated in vivo for clinical translation. Our results suggest that folic acid-nerve guidance conduits may offer significant benefits as a low-cost, off-the-shelf product for reaching the functional recovery seen with autografts in large sciatic nerve defects. Consequently, folic acid holds great potential as a critical and convenient therapeutic intervention for neural engineering, regenerative medicine, medical prosthetics, and drug delivery.
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影响因子：
3.4
作者：
Correale J;Farez MF
通讯作者：
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DOI：
10.1073/pnas.2336152100
发表时间：
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影响因子：
11.1
作者：
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DOI：
10.1111/j.1460-9568.2011.07724.x
发表时间：
2011-06
期刊：
The European journal of neuroscience
影响因子：
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作者：
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通讯作者：
Sabatier MJ