Spinal cord processing of cardiac nociception: are there sex differences between male and proestrous female rats?
Spinal cord processing of cardiac nociception: are there sex differences between male and proestrous female rats?
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DOI：
10.1016/j.brainres.2011.07.036
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发表时间：
2011-09-21
期刊：
影响因子：
2.9
通讯作者：
Foreman RD
中科院分区：
文献类型：
--
作者：
Little JM;Qin C;Farber JP;Foreman RD
临床研究报告了心脏疼痛特征的性别差异。例如，女性比男性更少经历胸痛。女性形容她们的胸痛是尖锐的，而男性的胸痛是一种压力或沉重。背部疼痛在女性中也比男性更常见。心脏疼痛的性别差异背后的机制尚不清楚。观察到的差异的一个可能机制可能与血浆雌二醇有关。本研究探讨了雌二醇对雄性和雌性大鼠处理心身信息的T3脊髓神经元活性的影响。研究了戊巴比妥麻醉雄性大鼠和发情雌性大鼠在机械躯体刺激和有害化学心脏刺激下T3脊髓神经元细胞外电位的变化。在雄性和雌性大鼠中，分别有51%和50%的神经元对心包内致痛化学物质（0.2 ml）有反应。用刷、压、捏等方法定位上半身体场。在接受心脏输入的神经元中，54%的雌性和55%的雄性大鼠也接受了体细胞输入。在雄性和雌性大鼠中，81%对躯体刺激有反应的神经元的躯体野位于上半身的一侧，而19%的神经元的躯体野位于胸部。这些结果表明，尽管雌二醇水平存在差异，但雄性和发情雌性大鼠的T3脊髓神经元对心性刺激的反应没有显著差异。
Sex differences in the characteristics of cardiac pain have been reported from clinical studies. For example, women experience chest pain less frequently than men. Women describe their chest pain as sharp and stabbing, while men have chest pain that is felt as a pressure or heaviness. Pain is also referred to the back more often in women than men. The mechanisms underlying sex differences in cardiac pain are unknown. One possible mechanism for the observed differences could be related to plasma estradiol. This study investigated the actions of estradiol on the activity of T3 spinal neurons that process cardiosomatic information in male and female rats. Extracellular potentials of T3 spinal neurons were recorded in response to mechanical somatic stimulation and noxious chemical cardiac stimulation in pentobarbital-anesthetized male and proestrous female rats. Fifty one percent and 50% of neurons responded to intrapericardial algogenic chemicals (0.2 ml) in male and female rats, respectively. Somatic fields were located by applying brush, pressure, and pinch to the upper body. Of those neurons receiving cardiac input, 54% in female and 55% in male rats also received somatic input. In both male and female rats, 81% of neurons responding to somatic stimuli had somatic fields located on the side of the upper body, while 19% of neurons had somatic fields located on the chest. These results indicate there are no significant differences in the responses of T3 spinal neurons to cardiosomatic stimulation between male and proestrous female rats, despite differences in estradiol levels.
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DOI：
10.1152/ajpregu.2000.279.2.r560
发表时间：
2000-08-01
影响因子：
2.8
作者：
Chandler, MJ;Zhang, JH;Foreman, RD
通讯作者：
Foreman, RD
影响因子：
29.4
作者：
Traub RJ;Tang B;Ji Y;Pandya S;Yfantis H;Sun Y
通讯作者：
Sun Y
影响因子：
3.3
作者：
Ji, Y.;Tang, B.;Traub, R. J.
通讯作者：
Traub, R. J.
影响因子：
7.4
作者：
EUCHNERWAMSER, I;MELLER, ST;GEBHART, GF
通讯作者：
GEBHART, GF
影响因子：
2.2
作者：
Lovlien, Mona;Schei, Berit;Hole, Torstein
通讯作者：
Hole, Torstein