Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes.

Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes.
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DOI:
10.1016/j.mib.2018.10.002
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发表时间:
2018-12
影响因子:
5.4
通讯作者:
Duraisingh MT
Duraisingh MT
中科院分区:
生物学2区
文献类型:
--
作者:
Kanjee U;Rangel GW;Clark MA;Duraisingh MT

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Plasmodium vivax is uniquely restricted to invading reticulocytes, the youngest of red blood cells. Parasite invasion relies on the sequential deployment of multiple parasite invasion ligands. Correct targeting of the host reticulocyte is mediated by two families of invasion ligands: the reticulocyte binding proteins (RBPs) and erythrocyte binding proteins (EBPs). The Duffy receptor has long been established as a key determinant for P. vivax invasion. However, recently, the RBP protein PvRBP2b has been shown to bind to transferrin receptor, which is expressed on reticulocytes but lost on normocytes, implicating the ligand-receptor in the reticulocyte tropism of P. vivax. Furthermore there is increasing evidence for P. vivax growth and sexual development in reticulocyte-enriched tissues such as the bone marrow.
DOI: 10.1016/j.ijpara.2016.10.002
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