Diagnosis of Biofilm-Associated Peri-Implant Disease Using a Fluorescence-Based Approach.
Diagnosis of Biofilm-Associated Peri-Implant Disease Using a Fluorescence-Based Approach.
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DOI：
10.3390/dj9030024
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发表时间：
2021-02-27
影响因子：
2.6
通讯作者：
Steier L
中科院分区：
文献类型：
--
作者：
Hwang G;Blatz MB;Wolff MS;Steier L
种植牙已成为日常牙科治疗的常规组成部分，预计未来对种植牙的需求将显著增加。尽管种植牙的成功率很高，但失败的情况时有发生，导致不适，严重破坏口腔健康，或痛苦和昂贵的手术更换失败的种植体。种植体周围疾病是影响功能性牙种植体周围软/硬组织的炎症性疾病。大量的实验证据表明，牙菌斑在软组织-种植体界面的积累和随后的局部炎症反应似乎是种植体周围粘膜炎发病的关键。这种种植体周围-软组织界面在抵抗细菌入侵方面不如天然牙齿有效，增加了随后种植体周围疾病的易感性。此外，在某些个体中，它会发展为种植体周围炎，导致牙槽骨丢失和种植体失效。尽管早期诊断和准确识别危险因素对于有效预防种植体周围疾病非常重要，但目前的系统综述显示，种植体周围炎缺乏统一的分类和诊断方法。基于荧光技术的最新进展使疾病的快速诊断和斑块的有效清除成为可能。在这里，我们简要回顾了生物膜相关的种植体周围疾病，并提出了一种基于荧光的更准确和客观的诊断方法。一种基于荧光的诊断工具，通过车头灯与特殊过滤的牙镜相结合，可以作为一种无需手动的解决方案，既可以精确诊断，又可以有效去除牙菌斑生物膜。
Dental implants have become a routine component of daily dental practice and the demand for dental implants is expected to increase significantly in the future. Despite the high success rates of dental implants, failures do occur, resulting in discomfort, rampant destruction of the oral health, or painful and costly surgical replacement of a failed implant. Peri-implant diseases are inflammatory conditions affecting the soft/hard tissues surrounding a functional dental implant. Plenty of experimental evidence indicates that the accumulation of dental plaque at the soft tissue–implant interface and the subsequent local inflammatory response seems to be key in the pathogenesis of the peri-implant mucositis. Such peri-implant–soft tissue interface is less effective than natural teeth in resisting bacterial invasion, enhancing vulnerability to subsequent peri-implant disease. Furthermore, in certain individuals, it will progress to peri-implantitis, resulting in alveolar bone loss and implant failure. Although early diagnosis and accurate identification of risk factors are extremely important to effectively prevent peri-implant diseases, current systematic reviews revealed that a uniform classification and diagnostic methodology for peri-implantitis are lacking. Recent progress on fluorescence-based technology enabled rapid diagnosis of the disease and effective removal of plaques. Here, we briefly review biofilm-associated peri-implant diseases and propose a fluorescence-based approach for more accurate and objective diagnoses. A fluorescence-based diagnosis tool through headlights combined with special-filtered dental loupes may serve as a hands-free solution for both precise diagnosis and effective removal of plaque-biofilms.
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