Effects of age and knee osteoarthritis on the modular control of walking: A pilot study.
Effects of age and knee osteoarthritis on the modular control of walking: A pilot study.
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DOI：
10.1371/journal.pone.0261862
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Siston RA
中科院分区：
文献类型：
--
作者：
Roelker SA;Koehn RR;Caruthers EJ;Schmitt LC;Chaudhari AMW;Siston RA
老年人和膝骨关节炎（KOA）患者通常表现出运动功能降低和肌肉活动改变。确定年龄和KOA相关的变化，步态的模块化控制，可以提供洞察神经机制的基础上减少行走性能在这些人群中。这项初步研究的目的是确定无KOA的年轻和老年人与终末期KOA的成年人之间的步行模块控制是否不同。收集了10名年轻（23.5 ± 3.1岁）和10名老年（63.5 ± 3.4岁）无KOA的成年人和10名KOA成年人（64.0 ± 4.0岁）以自选速度行走的运动学、动力学和肌电图数据。500个自举样本的单独非负矩阵分解确定了重建每个参与者的肌电图所需的模块数量。单因素方差分析检验评估了组对步行速度和模块数量的影响。Kendall秩相关系数（τB）评估了模块数量与自选步行速度之间的关联。年轻人所需的模块数量（3.2 ± 0.4）大于KOA患者（2.3 ± 0.7; p = 0.002），尽管两个队列所需的模块数量与未受损老年人（2.7 ± 0.5; p ≥ 0.113）均无显著差异。观察到模块数量与步行速度之间存在显著相关性（τB = 0.350，p = 0.021），KOA患者的步行速度（0.095 ± 0.21 m/s）明显低于年轻成人（1.24 ± 0.15 m/s; p = 0.005）。与未受损的成年人相比，KOA患者还表现出模块激活模式和组成（与每个模块相关的肌肉）的改变。这些发现表明，单独的老化可能不会显著改变模块控制;然而，膝关节骨关节炎和老化的综合影响可能共同损害步态的模块控制。
Older adults and individuals with knee osteoarthritis (KOA) often exhibit reduced locomotor function and altered muscle activity. Identifying age- and KOA-related changes to the modular control of gait may provide insight into the neurological mechanisms underlying reduced walking performance in these populations. The purpose of this pilot study was to determine if the modular control of walking differs between younger and older adults without KOA and adults with end-stage KOA. Kinematic, kinetic, and electromyography data were collected from ten younger (23.5 ± 3.1 years) and ten older (63.5 ± 3.4 years) adults without KOA and ten adults with KOA (64.0 ± 4.0 years) walking at their self-selected speed. Separate non-negative matrix factorizations of 500 bootstrapped samples determined the number of modules required to reconstruct each participant’s electromyography. One-way Analysis of Variance tests assessed the effect of group on walking speed and the number of modules. Kendall rank correlations (τb) assessed the association between the number of modules and self-selected walking speed. The number of modules required in the younger adults (3.2 ± 0.4) was greater than in the individuals with KOA (2.3 ± 0.7; p = 0.002), though neither cohorts’ required number of modules differed significantly from the unimpaired older adults (2.7 ± 0.5; p ≥ 0.113). A significant association between module number and walking speed was observed (τb = 0.350, p = 0.021) and individuals with KOA walked significantly slower (0.095 ± 0.21 m/s) than younger adults (1.24 ± 0.15 m/s; p = 0.005). Individuals with KOA also exhibited altered module activation patterns and composition (which muscles are associated with each module) compared to unimpaired adults. These findings suggest aging alone may not significantly alter modular control; however, the combined effects of knee osteoarthritis and aging may together impair the modular control of gait.
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