Mechanisms of Normal Tissue Injury From Irradiation.
Mechanisms of Normal Tissue Injury From Irradiation.
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DOI:
10.1016/j.semradonc.2017.04.001
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发表时间:
2017-10
影响因子:
3.5
通讯作者:
Mitchell JB
中科院分区:
文献类型:
--
作者:
Citrin DE;Mitchell JB
Normal tissue injury from irradiation is an unfortunate consequence of radiotherapy. Technologic improvements have reduced the risk of normal tissue injury, however toxicity causing treatment breaks or long term side effects continue to occur in a subset of patients. The molecular events that lead to normal tissue injury are complex and span a variety of biologic processes, including oxidative stress, inflammation, depletion of injured cells, senescence, and elaboration of pro-inflammatory and pro-fibrogenic cytokines. This manuscript describes selected recent advances in normal tissue radiobiology.
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DOI:
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期刊:
Annual review of pathology
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