Tolerance to amphetamine hypophagia: a microstructural analysis of licking behavior in the rat.

Tolerance to amphetamine hypophagia: a microstructural analysis of licking behavior in the rat.
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对安非他明吞咽不足的耐受性:大鼠舔行为的微观结构分析。

DOI:
10.1037//0735-7044.117.1.95
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发表时间:
2003
影响因子:
1.9
通讯作者:
Jakubow,JamesJ
Jakubow,JamesJ
中科院分区:
医学4区
文献类型:
--
作者:
Wolgin,DavidL;Jakubow,JamesJ

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通过记录长期给予药物(2 mg/kg)并获得甜牛奶的大鼠的舔体参数变化,评估对苯丙胺诱导的摄食量减少的耐受性。虽然舔乳和牛奶摄入量逐渐恢复,但每次舔乳摄入的牛奶量仍然受到抑制。安非他明对interlick间隔或每次舔力没有影响。相比之下,药物导致舔爆发次数持续增加(由0.5-2.0 s的暂停标准定义)和每次爆发舔次数减少(但仅在0.5和1.0 s的暂停标准下)。这些结果表明,耐受大鼠经常中断舔,导致效率较低的牛奶捕获。(PsycInfo数据库记录(c)2023阿帕,保留所有权利)
The development of tolerance to amphetamine-induced hypophagia was assessed by recording changes in lick parameters in rats given chronic administration of the drug (2 mg/kg) and access to sweetened milk. Although licking and milk intake gradually recovered, the volume of milk ingested per lick remained suppressed. Amphetamine had no effect on the interlick interval or the force per lick. In contrast, the drug caused a sustained increase in the number of lick bursts (defined by pause criteria of 0.5-2.0 s) and a decrease in the number of licks per burst (but only at pause criteria of 0.5 and 1.0 s). These results suggest that tolerant rats frequently interrupt licking, resulting in less efficient capture of milk.(PsycInfo Database Record (c) 2023 APA, all rights reserved)
对安非他明对内部时钟速度的加速作用产生持久的敏感性
DOI: --
发表时间: 1999
影响因子: 2.7
作者:
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