Surfactant-induced Marangoni transport of lipids and therapeutics within the lung.
Surfactant-induced Marangoni transport of lipids and therapeutics within the lung.
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DOI：
10.1016/j.cocis.2018.01.001
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发表时间：
2018-07
影响因子：
8.9
通讯作者：
Tilton RD
中科院分区：
文献类型：
--
作者：
Stetten AZ;Iasella SV;Corcoran TE;Garoff S;Przybycien TM;Tilton RD
了解粘性薄膜表面转运的基本原理在肺部给药中具有重要的应用。人的肺在其复杂的流体衬里和吸入的空气之间包含大面积的界面。由表面张力梯度驱动的Marangoni流动沿着该界面将促进吸入治疗剂的增强分布，这是通过将它们从它们沉积在上气道中的地方，沿着流体界面运送到肺的更深区域。出于改善急性和慢性肺部疾病治疗的潜力，我们回顾了最近在Marangoni运输的建模和实验研究中的进展，由含有表面活性剂的微升液滴和液体气溶胶（皮升液滴）沉积到流体界面上引起的。确定了关键系统变量的作用，包括表面活性剂的溶解度，液滴与亚相的可溶解性，以及亚相液体的厚度，组成和表面性质。特别令人感兴趣的是气溶胶处理通过磷脂囊泡分散体实现马兰戈尼转运的未预料到但至关重要的作用，磷脂囊泡分散体可能是生物相容性递送系统的候选物。这一领域的进展不仅有可能改善慢性和急性肺部疾病患者的预后，而且还可能进一步加深我们对复杂系统中表面转运的理解。
Understanding the fundamentals of surface transport on thin viscous films has important application in pulmonary drug delivery. The human lung contains a large-area interface between its complex fluid lining and inhaled air. Marangoni flows driven by surface tension gradients along this interface would promote enhanced distribution of inhaled therapeutics by carrying them from where they are deposited in the upper airways, along the fluid interface to deeper regions of the lung. Motivated by the potential to improve therapies for acute and chronic lung diseases, we review recent progress in modeling and experimental studies of Marangoni transport induced by the deposition of surfactant-containing microliter drops and liquid aerosols (picoliter drops) onto a fluid interface. The roles of key system variables are identified, including surfactant solubility, drop miscibility with the subphase, and the thickness, composition and surface properties of the subphase liquid. Of particular interest is the unanticipated but crucial role of aerosol processing to achieve Marangoni transport via phospholipid vesicle dispersions, which are likely candidates for a biocompatible delivery system. Progress in this field has the potential to not only improve outcomes in patients with chronic and acute lung diseases, but also to further our understanding of surface transport in complex systems.
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DOI：
10.1126/science.1223012
发表时间：
2012-08-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Button B;Cai LH;Ehre C;Kesimer M;Hill DB;Sheehan JK;Boucher RC;Rubinstein M
通讯作者：
Rubinstein M
影响因子：
3.8
作者：
Bertram, C;Gaver, DP
通讯作者：
Gaver, DP
影响因子：
3.9
作者：
Buboltz, JT;Feigenson, GW
通讯作者：
Feigenson, GW
影响因子：
--
作者：
Charron, JR;Tilton, RD
通讯作者：
Tilton, RD
影响因子：
3.3
作者：
BROWN, ES;JOHNSON, RP;CLEMENTS, JA
通讯作者：
CLEMENTS, JA