Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease.
Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease.
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DOI：
10.3390/cells10040957
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发表时间：
2021-04-20
期刊：
影响因子：
6
通讯作者：
Reed-Geaghan EG
中科院分区：
文献类型：
--
作者：
Casali BT;Reed-Geaghan EG
小胶质细胞是大脑的常驻免疫细胞，起源于卵黄囊前体细胞，在发育过程中填充在脑实质中。在发育和动态平衡过程中，小胶质细胞除了作为免疫哨兵的主要作用外，还在突触发生和突触可塑性中发挥关键作用。在衰老和神经退行性疾病中，特别是阿尔茨海默病(AD)中，小胶质细胞功能的改变明显偏离其体内平衡状态，导致更有害的炎症环境。在这篇综述中，我们讨论了小胶质细胞的受体、信号、调节和基因表达模式，它们介导了小胶质细胞的表型和功能，有助于AD脑内的炎症环境，以及以小胶质细胞为靶点改善AD的发病、进展和症状的策略。
Microglia are the resident immune cells of the brain, deriving from yolk sac progenitors that populate the brain parenchyma during development. During development and homeostasis, microglia play critical roles in synaptogenesis and synaptic plasticity, in addition to their primary role as immune sentinels. In aging and neurodegenerative diseases generally, and Alzheimer’s disease (AD) specifically, microglial function is altered in ways that significantly diverge from their homeostatic state, inducing a more detrimental inflammatory environment. In this review, we discuss the receptors, signaling, regulation and gene expression patterns of microglia that mediate their phenotype and function contributing to the inflammatory milieu of the AD brain, as well as strategies that target microglia to ameliorate the onset, progression and symptoms of AD.
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影响因子：
16.2
作者：
Bhaskar, Kiran;Konerth, Megan;Kokiko-Cochran, Olga N.;Cardona, Astrid;Ransohoff, Richard M.;Lamb, Bruce T.
通讯作者：
Lamb, Bruce T.
影响因子：
34.7
作者：
Brown, Guy C.;Neher, Jonas J.
通讯作者：
Neher, Jonas J.
影响因子：
5.3
作者：
Bolmont, Tristan;Haiss, Florent;Calhoun, Michael E.
通讯作者：
Calhoun, Michael E.
DOI：
10.1126/science.1217697
发表时间：
2012-03-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cramer PE;Cirrito JR;Wesson DW;Lee CY;Karlo JC;Zinn AE;Casali BT;Restivo JL;Goebel WD;James MJ;Brunden KR;Wilson DA;Landreth GE
通讯作者：
Landreth GE
影响因子：
30.5
作者：
Buttgereit, Anne;Lelios, Iva;Greter, Melanie
通讯作者：
Greter, Melanie