Functional cure for chronic hepatitis B: accessibility, durability, and prognosis.

Functional cure for chronic hepatitis B: accessibility, durability, and prognosis.
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DOI:
10.1186/s12985-021-01589-x
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发表时间:
2021-06-03
期刊:
影响因子:
4.8
通讯作者:
Chen X
Chen X
中科院分区:
医学3区
文献类型:
--
作者:
Song A;Lin X;Chen X

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就停药安全性和改善预后而言,乙型肝炎表面抗原(HBsAg)清除被认为是抗病毒治疗的理想终点。然而,HBsAg 的总体清除率较低,并且根据治疗方法和疗程的不同而有所不同。近年来联合和延伸治疗策略的应用提高了HBsAg清除率,临床治疗中已有多名患者实现HBsAg清除。此外,HBsAg清除后的持久性和临床结果已成为研究人员和临床医生关注的焦点。本文从可及性、持久性、预后改善和相关进展方面回顾了 HBsAg 清除。
Hepatitis B surface antigen (HBsAg) clearance is regarded as the ideal endpoint for antiviral treatment in terms of drug withdrawal safety and improvements in prognosis. However, the overall rate of HBsAg clearance is low and differs based on treatment method and course. The recent application of combined and extended treatment strategies have improved the HBsAg clearance rate, and several patients achieved HBsAg clearance in clinical treatment. In addition, the durability of and clinical outcomes after HBsAg clearance have become the focus of both researchers and clinicians. This article reviews HBsAg clearance in terms of accessibility, durability, improvements in prognosis and relevant advances.
TLR8激动剂GS-9688(Selgantolimod)在慢性肝炎B中的治疗潜力:抗病毒和调节介质的重塑。
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