Resting state EEG power and coherence abnormalities in bipolar disorder and schizophrenia.
Resting state EEG power and coherence abnormalities in bipolar disorder and schizophrenia.
复制标题
DOI：
10.1016/j.jpsychires.2013.09.009
复制
发表时间：
2013-12
影响因子：
4.8
通讯作者：
Brenner, Colleen A.
中科院分区：
文献类型：
--
作者：
Kam, Julia W. Y.;Bolbecker, Amanda R.;O'Donnell, Brian F.;Hetrick, William P.;Brenner, Colleen A.
精神分裂症和双相情感障碍患者的静息状态脑电图异常提示神经振荡活动的改变。然而，很少有研究直接比较患者组之间的这些异常，也没有研究检查脑电图一致性。因此，本研究调查了这些电生理特征是否能将临床人群彼此区分开来，并与非精神病学对照组区分开来。为了解决这个问题，我们对76名双相情感障碍患者（BP）、132名精神分裂症患者（SZ）和136名非精神疾病对照（NC）的静息脑电图功率和一致性进行了评估。我们进行了单独的重复测量方差分析，以检查几个大脑区域的七个频段内的组差异。在包括Beta和Gamma在内的所有区域的较高频率上，BP表现出相对于SZ更大的功率。在半球内相干性方面，与NC和BP相比，SZ在Delta处具有更高的相干性，而SZ和BP在Alpha1和Alpha2处均具有更高的相干性。相比之下，与SZ相比，BP和HC在β 1时表现出更高的半球内相干性。在半球间相干性方面，SZ在Alpha1和Alpha2的时间位点表现出比NC更高的相干性。综上所述，BP表现出高频功率增加，神经同步几乎没有中断。相比之下，SZ在半球内和半球间普遍表现出增强的同步。这些发现提示静息脑电图可作为区分临床疾病的敏感指标。
Resting state electroencephalogram (EEG) abnormalities in schizophrenia and bipolar disorder patients suggest alterations in neural oscillatory activity. However, few studies directly compare these anomalies between patient groups, and none have examined EEG coherence. Therefore, this study investigated whether these electrophysiological characteristics differentiate clinical populations from one another, and from non-psychiatric controls. To address this question, resting EEG power and coherence were assessed in 76 bipolar patients (BP), 132 schizophrenia patients (SZ), and 136 non-psychiatric controls (NC). We conducted separate repeated-measures ANOVAs to examine group differences within seven frequency bands across several brain regions. BP showed significantly greater power relative to SZ at higher frequencies including Beta and Gamma across all regions. In terms of intra-hemispheric coherence, while SZ generally exhibited higher coherence at Delta compared to NC and BP, both SZ and BP showed higher coherence at Alpha1 and Alpha2. In contrast, BP and HC showed higher coherence within hemispheres compared to SZ at Beta 1. In terms of inter-hemispheric coherence, SZ displayed higher coherence compared to NC at temporal sites at both Alpha1 and Alpha2. Taken together, BP exhibited increased high frequency power with few disruptions in neural synchronization. In contrast, SZ generally exhibited enhanced synchronization within and across hemispheres. These findings suggest that resting EEG can be a sensitive measure for differentiating between clinical disorders.
登录
查看更多内容
影响因子：
5.7
作者：
Britz, Juliane;Van De Ville, Dimitri;Michel, Christoph M.
通讯作者：
Michel, Christoph M.
影响因子：
4.8
作者：
Karch, Susanne;Leicht, Gregor;Mulert, Christoph
通讯作者：
Mulert, Christoph
影响因子：
3.7
作者：
Finnigan, Simon;Robertson, Ian H.
通讯作者：
Robertson, Ian H.
影响因子：
2.5
作者：
Chen, Shyan-Shiou;Tu, Pei-Chi;Chen, Li-Fen
通讯作者：
Chen, Li-Fen
影响因子：
3.1
作者：
Iqbal, Z;Birchwood, M;Morris, E
通讯作者：
Morris, E