Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2.
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2.
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DOI：
10.1038/s41590-023-01724-6
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发表时间：
2024-02
影响因子：
30.5
通讯作者：
Roan, Nadia R.
中科院分区：
文献类型：
--
作者：
Yin, Kailin;Peluso, Michael J.;Luo, Xiaoyu;Thomas, Reuben;Shin, Min-Gyoung;Neidleman, Jason;Andrew, Alicer;Young, Kyrlia C.;Ma, Tongcui;Hoh, Rebecca;Anglin, Khamal;Huang, Beatrice;Argueta, Urania;Lopez, Monica;Valdivieso, Daisy;Asare, Kofi;Deveau, Tyler-Marie;Munter, Sadie E.;Ibrahim, Rania;Staendker, Ludger;Lu, Scott;Goldberg, Sarah A.;Lee, Sulggi A.;Lynch, Kara L.;Kelly, J. Daniel;Martin, Jeffrey N.;Muench, Jan;Deeks, Steven G.;Henrich, Timothy J.;Roan, Nadia R.
长期COVID（LC）发生在至少10%的严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）感染后，但其病因仍知之甚少。我们使用“组学”检测和血清学来深入表征感染后8个月具有明确LC和非LC临床轨迹的个体血液中的全局和SARS-CoV-2特异性免疫。我们发现LC个体表现出全身炎症和免疫失调。T细胞亚群分布的总体差异表明正在进行的免疫应答，以及溶细胞亚群的性别特异性扰动证明了这一点。LC个体表现出增加的CD 4 + T细胞倾向于迁移到发炎组织和耗尽的SARS-CoV-2特异性CD 8 + T细胞的频率，更高水平的SARS-CoV-2抗体和他们的SARS-CoV-2特异性T和B细胞反应之间的不协调。我们的分析表明LC中细胞和体液适应性免疫之间存在不适当的串扰，这可能导致免疫失调，炎症和与这种衰弱状况相关的临床症状。Roan等人使用Olink和单细胞RNA测序（scRNA-seq）显示了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染后8个月长期COVID患者的细胞和体液免疫应答之间的失调串扰。
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used ‘omic” assays and serology to deeply characterize the global and SARS-CoV-2-specific immunity in the blood of individuals with clear LC and non-LC clinical trajectories, 8 months postinfection. We found that LC individuals exhibited systemic inflammation and immune dysregulation. This was evidenced by global differences in T cell subset distribution implying ongoing immune responses, as well as by sex-specific perturbations in cytolytic subsets. LC individuals displayed increased frequencies of CD4+ T cells poised to migrate to inflamed tissues and exhausted SARS-CoV-2-specific CD8+ T cells, higher levels of SARS-CoV-2 antibodies and a mis-coordination between their SARS-CoV-2-specific T and B cell responses. Our analysis suggested an improper crosstalk between the cellular and humoral adaptive immunity in LC, which can lead to immune dysregulation, inflammation and clinical symptoms associated with this debilitating condition. Roan et al. use Olink and single‐cell RNA sequencing (scRNA-seq) to show a dysregulated crosstalk between the cellular and humoral immune responses in individuals with long COVID 8 months postinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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影响因子：
48
作者：
Huber W;Carey VJ;Gentleman R;Anders S;Carlson M;Carvalho BS;Bravo HC;Davis S;Gatto L;Girke T;Gottardo R;Hahne F;Hansen KD;Irizarry RA;Lawrence M;Love MI;MacDonald J;Obenchain V;Oleś AK;Pagès H;Reyes A;Shannon P;Smyth GK;Tenenbaum D;Waldron L;Morgan M
通讯作者：
Morgan M
DOI：
10.1038/s41579-022-00846-2
发表时间：
2023-03
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
--
影响因子：
32.4
作者：
Ferretti AP;Kula T;Wang Y;Nguyen DMV;Weinheimer A;Dunlap GS;Xu Q;Nabilsi N;Perullo CR;Cristofaro AW;Whitton HJ;Virbasius A;Olivier KJ Jr;Buckner LR;Alistar AT;Whitman ED;Bertino SA;Chattopadhyay S;MacBeath G
通讯作者：
MacBeath G
DOI：
10.1093/bioinformatics/btaa1009
发表时间：
2021-04-05
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Ahlmann-Eltze C;Huber W
通讯作者：
Huber W
影响因子：
14.9
作者：
The Gene Ontology Consortium
通讯作者：
The Gene Ontology Consortium