Long COVID: major findings, mechanisms and recommendations.
Long COVID: major findings, mechanisms and recommendations.
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DOI：
10.1038/s41579-022-00846-2
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发表时间：
2023-03
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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长期COVID是一种通常使人衰弱的疾病，至少有10%的严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）感染者会发生这种疾病。已发现200多种对多器官系统产生影响的症状。据估计，全球至少有6500万人长期患有COVID，病例每天都在增加。生物医学研究在确定各种病理生理变化和风险因素以及疾病特征方面取得了重大进展;此外，与其他病毒性疾病，如肌痛性脑脊髓炎/慢性疲劳综合征和体位性直立性心动过速综合征的相似性为该领域的研究奠定了基础。在这篇综述中，我们探讨了当前的文献，并强调了关键的发现，与其他疾病的重叠，症状的可变发作，儿童的长期COVID以及疫苗接种的影响。尽管这些关键发现对于理解长期COVID至关重要，但目前的诊断和治疗方案是不够的，必须优先考虑解决主要假设的临床试验。此外，为了加强长期的COVID研究，未来的研究必须考虑偏见和SARS-CoV-2测试问题，建立在病毒发作研究的基础上，包括边缘化人群，并在整个研究过程中有意义地吸引患者参与。长期COVID是一种通常使人衰弱的疾病，症状严重，可在COVID-19期间或之后发展。在这篇评论中，Davis、McCorkell、Vogel和Topol探讨了我们对长期COVID的了解，并强调了关键发现，包括潜在的机制、与其他疾病的重叠以及潜在的治疗方法。他们还讨论了长期COVID研究和护理的挑战和建议。
Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million individuals worldwide are estimated to have long COVID, with cases increasing daily. Biomedical research has made substantial progress in identifying various pathophysiological changes and risk factors and in characterizing the illness; further, similarities with other viral-onset illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome and postural orthostatic tachycardia syndrome have laid the groundwork for research in the field. In this Review, we explore the current literature and highlight key findings, the overlap with other conditions, the variable onset of symptoms, long COVID in children and the impact of vaccinations. Although these key findings are critical to understanding long COVID, current diagnostic and treatment options are insufficient, and clinical trials must be prioritized that address leading hypotheses. Additionally, to strengthen long COVID research, future studies must account for biases and SARS-CoV-2 testing issues, build on viral-onset research, be inclusive of marginalized populations and meaningfully engage patients throughout the research process. Long COVID is an often debilitating illness of severe symptoms that can develop during or following COVID-19. In this Review, Davis, McCorkell, Vogel and Topol explore our knowledge of long COVID and highlight key findings, including potential mechanisms, the overlap with other conditions and potential treatments. They also discuss challenges and recommendations for long COVID research and care.
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DOI：
10.1136/bjophthalmol-2021-319450
发表时间：
2022-12
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Bitirgen G;Korkmaz C;Zamani A;Ozkagnici A;Zengin N;Ponirakis G;Malik RA
通讯作者：
Malik RA
影响因子：
82.9
作者：
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通讯作者：
Al-Aly, Ziyad
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DOI：
10.15585/mmwr.mm7121e1
发表时间：
2022-05-27
期刊：
Morbidity and Mortality Weekly Report
影响因子：
--
作者：
通讯作者：
--
影响因子：
1.6
作者：
Bitirgen G;Korkmaz C;Zamani A;Iyisoy MS;Kerimoglu H;Malik RA
通讯作者：
Malik RA
影响因子：
4.7
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通讯作者：
Burki, Carolina