Transcriptome sequencing analysis of echovirus 30 infection reveals its potential pathogenesis.
Transcriptome sequencing analysis of echovirus 30 infection reveals its potential pathogenesis.
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艾柯病毒30感染的转录组测序分析揭示其潜在发病机制
DOI：
10.3389/fmicb.2022.958385
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
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作者：
Echovirus 30 (E30) causes various diseases, such as viral encephalitis; aseptic meningitis; hand, foot, and mouth diseases; and acute flaccid paralysis. Related neurological infections are most concerning. However, the molecular mechanisms of E30 pathogenesis are not fully understood. There is a growing research interest in E30 as a cause of neurological disease. The aim of this study was to describe E30 infection, especially the changes in differential factor expressions after infection, in human glioma (U251) cells and mice brains using transcriptome sequencing analysis. Clear changes in the gene expression of factors associated with the defense response to viruses, inflammation-related signaling pathways, and neurological complication-related pathways were observed. Our results suggest that after E30 infection, the genes related to immune response were induced in the human glioma cells and mice brains, whereas genes functioning in the development and function of neural tissue were inhibited. Overall, this study successfully established E30 infection of U251 and mouse brain tissue, profiled the infection-induced changes in cellular and organizational transcriptomes, and revealed the molecular level changes during E30 infection.
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DOI：
10.3390/v13122477
发表时间：
2021-12-10
期刊：
Viruses
影响因子：
--
作者：
Zhang G;Li J;Sun Q;Zhang K;Xu W;Zhang Y;Wu G
通讯作者：
Wu G
影响因子：
11.8
作者：
Benschop KSM;Broberg EK;Hodcroft E;Schmitz D;Albert J;Baicus A;Bailly JL;Baldvinsdottir G;Berginc N;Blomqvist S;Böttcher S;Brytting M;Bujaki E;Cabrerizo M;Celma C;Cinek O;Claas ECJ;Cremer J;Dean J;Dembinski JL;Demchyshyna I;Diedrich S;Dudman S;Dunning J;Dyrdak R;Emmanouil M;Farkas A;De Gascun C;Fournier G;Georgieva I;Gonzalez-Sanz R;van Hooydonk-Elving J;Jääskeläinen AJ;Jancauskaite R;Keeren K;Fischer TK;Krokstad S;Nikolaeva-Glomb L;Novakova L;Midgley SE;Mirand A;Molenkamp R;Morley U;Mossong J;Muralyte S;Murk JL;Nguyen T;Nordbø SA;Österback R;Pas S;Pellegrinelli L;Pogka V;Prochazka B;Rainetova P;Van Ranst M;Roorda L;Schuffenecker I;Schuurman R;Stoyanova A;Templeton K;Verweij JJ;Voulgari-Kokota A;Vuorinen T;Wollants E;Wolthers KC;Zakikhany K;Neher R;Harvala H;Simmonds P
通讯作者：
Simmonds P
影响因子：
4.6
作者：
Ledur, Pitia Flores;Karmirian, Karina;Rehen, Stevens Kastrup
通讯作者：
Rehen, Stevens Kastrup
肠道病毒 71 型和柯萨奇病毒 A16 感染呼吸道上皮细胞后的转录组分析
影响因子：
2.7
作者：
Song J;Hu Y;Li W;Li H;Zheng H;Chen Y;Dong S;Liu L
通讯作者：
Liu L
影响因子：
4.5
作者：
Poma，Anello Marcello;Genoni，Angelo;Toniolo，Antonio
通讯作者：
Toniolo，Antonio