Differential Emergence and Stability of Sensory and Temporal Representations in Context-Specific Hippocampal Sequences.
Differential Emergence and Stability of Sensory and Temporal Representations in Context-Specific Hippocampal Sequences.
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情境特异性海马序列中感觉表征和时间表征的差异出现和稳定性。
DOI：
10.1016/j.neuron.2020.08.028
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发表时间：
2020-12-09
期刊：
影响因子：
16.2
通讯作者：
Golshani P
中科院分区：
文献类型：
--
作者：
Taxidis J;Pnevmatikakis EA;Dorian CC;Mylavarapu AL;Arora JS;Samadian KD;Hoffberg EA;Golshani P
海马峰电位序列编码外部刺激和时空间隔，将记忆中的顺序经验联系起来，但控制这种不同表征的出现和稳定性的动力学仍不清楚。在CA1中使用双光子钙成像，当小鼠执行嗅觉工作记忆任务时，我们记录了编码嗅觉刺激的刺激特定序列的气味细胞，随后是编码随后延迟的时间点的时间细胞。气味细胞被可靠地激活，并在试验结构变化期间和几天内保持稳定的电场。时间细胞在这两种情况下都表现出稀疏和动态的重新映射的场。在任务训练期间，但不是在未经训练的任务暴露中，时间细胞集合的大小增加，而气味细胞的数量保持稳定。几天后，序列漂移到新的种群，细胞活动逐渐汇聚到一块田地，然后又偏离它。因此，CA1使用不同的机制来编码外部线索与其可变的时间关系，这可能是构建顺序经验地图所必需的。Taxidis等人。证明海马体中气味特定的尖峰序列将嗅觉刺激的稳健稳定编码与高度动态的时间代码结合在一起，这些代码在学习工作记忆任务时会增加。这种组合允许链接固定的外部元素及其在存储空间中的可变时间关系。
Hippocampal spiking sequences encode external stimuli and spatiotemporal intervals, linking sequential experiences in memory, but the dynamics controlling the emergence and stability of such diverse representations remain unclear. Using two-photon calcium imaging in CA1, while mice performed an olfactory working-memory task, we recorded stimulus-specific sequences of ‘odor-cells’ encoding olfactory stimuli, followed by ‘time-cells’ encoding time-points in the ensuing delay. Odor-cells were reliably activated and retained stable fields during changes in trial structure and across days. Time-cells exhibited sparse and dynamic fields that remapped in both cases. During task training, but not in untrained task exposure, time-cell ensembles increased in size whereas odor-cell numbers remained stable. Over days, sequences drifted to new populations with cell activity progressively converging to a field and then diverging from it. Therefore, CA1 employs distinct regimes to encode external cues versus their variable temporal relationships which may be necessary to construct maps of sequential experiences. Taxidis et al. demonstrate that odor-specific spiking sequences in the hippocampus combine robust and stable encoding of olfactory stimuli with highly dynamic temporal codes that increase during learning of a working memory task. This combination allows linking fixed external elements and their variable temporal relationships in memory space.
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影响因子：
25
作者：
Kamiński J;Sullivan S;Chung JM;Ross IB;Mamelak AN;Rutishauser U
通讯作者：
Rutishauser U
影响因子：
5.3
作者：
Diba, Kamran;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy
DOI：
10.1523/jneurosci.0154-12.2012
发表时间：
2012-06-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Igarashi KM;Ieki N;An M;Yamaguchi Y;Nagayama S;Kobayakawa K;Kobayakawa R;Tanifuji M;Sakano H;Chen WR;Mori K
通讯作者：
Mori K
影响因子：
5.3
作者：
Howard, Marc W.;MacDonald, Christopher J.;Eichenbaum, Howard
通讯作者：
Eichenbaum, Howard
DOI：
10.1126/science.aan8869
发表时间：
2017-10-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Buzsáki G;Llinás R
通讯作者：
Llinás R