Mesenchymal stem cell therapy for liver disease: full of chances and challenges.
Mesenchymal stem cell therapy for liver disease: full of chances and challenges.
复制标题
间充质干细胞治疗肝病：充满机遇与挑战
DOI：
10.1186/s13578-020-00480-6
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发表时间：
2020
影响因子：
7.5
通讯作者：
Zong C
中科院分区：
文献类型：
--
作者：
Yang X;Meng Y;Han Z;Ye F;Wei L;Zong C
肝病是世界范围内危害人类健康的重大健康问题。目前，全器官同种异体移植是治疗终末期肝病的金标准。合适的器官短缺、昂贵的费用和手术并发症限制了肝移植的应用。间充质干细胞治疗被认为是治疗终末期肝病的一种有前途的替代方法。一些临床试验证实了MSC治疗肝脏疾病的有效性，但其应用尚未得到推广和批准。在临床应用骨髓间充质干细胞疗法之前，仍有许多问题需要解决。应确定最适合MSC应用的肝病类型，并规范MSCs的制备和植入。这些可能是限制间充质干细胞使用的瓶颈。我们调查了22个已完成和几个正在进行的临床试验，从临床角度讨论这些问题。我们还讨论了MSCs在肝脏疾病中发挥治疗作用的重要机制。最后，我们还提出了新的前瞻性方法，可以提高MSCs的治疗效果。
Liver disease is a major health problem that endangers human health worldwide. Currently, whole organ allograft transplantation is the gold standard for the treatment of end-stage liver disease. A shortage of suitable organs, high costs and surgical complications limit the application of liver transplantation. Mesenchymal stem cell therapy has been considered as a promising alternative approach for end-stage liver disease. Some clinical trials have confirmed the effectiveness of MSC therapy for liver disease, but its application has not been promoted and approved. There are still many issues that should be solved prior to using MSC therapy in clinical applications. The types of liver disease that are most suitable for MSC application should be determined, and the preparation and engraftment of MSCs should be standardized. These may be bottlenecks that limit the use of MSCs. We investigated 22 completed and several ongoing clinical trials to discuss these questions from a clinical perspective. We also discussed the important mechanisms by which MSCs play a therapeutic role in liver disease. Finally, we also proposed novel prospective approaches that can improve the therapeutic effect of MSCs.
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影响因子：
1.4
作者：
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通讯作者：
Hattiholi J
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56.9
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通讯作者：
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通讯作者：
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影响因子：
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作者：
Erices, A;Conget, P;Minguell, JJ
通讯作者：
Minguell, JJ