NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications.
NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications.
复制标题
NF-κB通路在多发性硬化发病机制中的作用及其治疗意义。
DOI：
10.3389/fnmol.2016.00084
复制
发表时间：
2016
影响因子：
4.8
通讯作者：
Yan J
中科院分区：
文献类型：
--
作者：
Leibowitz SM;Yan J
活化B细胞核因子κ轻链增强子（NF-κB）信号通路参与细胞免疫应答、凋亡和感染。在多发性硬化症（MS）中，NF-κB通路发生改变，导致细胞中NF-κB活化水平升高。提示NF-κB在MS发病机制中起重要作用。NF-κB信号转导是一个复杂的过程，其激活和调节涉及多种因素。有趣的是，发现目前的MS治疗与NF-κB通路直接或间接相关，并可调节患者的先天性和适应性免疫系统。本文首先对NF-κB信号通路及其调控元件进行综述。接下来，我们将根据目前的研究结果，从理论上阐述NF-κB在MS发病机制中的作用，并讨论一些相关的治疗意义。最后，我们将回顾四种阻断NF-κB通路的MS新治疗方法-芬戈莫德、特立氟胺、富马酸二甲酯（DMF）和拉喹莫德（LAQ）-并解释其机制，以及未来MS治疗的可能策略。
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathways are involved in cell immune responses, apoptosis and infections. In multiple sclerosis (MS), NF-κB pathways are changed, leading to increased levels of NF-κB activation in cells. This may indicate a key role for NF-κB in MS pathogenesis. NF-κB signaling is complex, with many elements involved in its activation and regulation. Interestingly, current MS treatments are found to be directly or indirectly linked to NF-κB pathways and act to adjust the innate and adaptive immune system in patients. In this review, we will first focus on the intricacies of NF-κB signaling, including the activating pathways and regulatory elements. Next, we will theorize about the role of NF-κB in MS pathogenesis, based on current research findings, and discuss some of the associated therapeutic implications. Lastly, we will review four new MS treatments which interrupt NF-κB pathways—fingolimod, teriflunomide, dimethyl fumarate (DMF) and laquinimod (LAQ)—and explain their mechanisms, and the possible strategy for MS treatments in the future.
登录
查看更多内容
影响因子：
64.8
作者：
Belich, MP;Salmerón, A;Ley, SC
通讯作者：
Ley, SC
影响因子：
158.5
作者：
Comi, Giancarlo;Jeffery, Douglas;Filippi, Massimo
通讯作者：
Filippi, Massimo
影响因子：
7
作者：
Becher B;Segal BM
通讯作者：
Segal BM
影响因子：
9.3
作者：
Alboni S;Cervia D;Sugama S;Conti B
通讯作者：
Conti B
影响因子：
4.4
作者：
Calabrese, V;Scapagnini, G;Stella, AMG
通讯作者：
Stella, AMG