Cholinergic modulation of the hippocampal region and memory function.
Cholinergic modulation of the hippocampal region and memory function.
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DOI：
10.1111/jnc.14052
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发表时间：
2017-08
影响因子：
4.7
通讯作者：
Yakel JL
中科院分区：
文献类型：
--
作者：
Haam J;Yakel JL
Acetylcholine (ACh) plays an important role in memory function and has been implicated in aging-related dementia, in which the impairment of hippocampus-dependent learning strongly manifests. Cholinergic neurons densely innervate the hippocampus, mediating the formation of episodic as well as semantic memory. Here, we will review recent findings on acetylcholine’s modulation of memory function, with a particular focus on hippocampus-dependent learning, and the circuits involved. In addition, we will discuss the complexity of ACh actions in memory function to better understand the physiological role of ACh in memory. The neuromodulator acetylcholine (ACh) plays a critical role in memory function, especially in the hippocampus-dependent learning. The cholinergic system is severely affected in Alzheimer’s disease, implicating its role in memory. In this review, the current knowledge on the cholinergic system and its modulation of hippocampal circuits have been reviewed. Furthermore, we describe factors that contribute to the complexity of ACh actions in memory function.
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影响因子：
4.7
作者：
Bell, Karen A.;Shim, Hoon;Chen, Ching-Kang;McQuiston, A. Rory
通讯作者：
McQuiston, A. Rory
DOI：
10.3109/10799899709036607
发表时间：
1997-01-01
期刊：
JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH
影响因子：
--
作者：
Albuquerque, EX;Pereira, EFR;Maelicke, A
通讯作者：
Maelicke, A
DOI：
10.1124/jpet.108.145292
发表时间：
2009-02-01
影响因子：
3.5
作者：
Buccafusco, Jerry J.;Beach, J. Warren;Terry, Alvin V., Jr.
通讯作者：
Terry, Alvin V., Jr.
哺乳动物烟碱乙酰胆碱受体：从结构到功能。
影响因子：
33.6
作者：
Albuquerque EX;Pereira EF;Alkondon M;Rogers SW
通讯作者：
Rogers SW
影响因子：
14.5
作者：
Baker-Nigh, Alaina;Vahedi, Shahrooz;Geula, Changiz
通讯作者：
Geula, Changiz