Epigenetic regulation of energy metabolism in obesity.
Epigenetic regulation of energy metabolism in obesity.
复制标题
肥胖能量代谢的表观遗传调控。
DOI：
10.1093/jmcb/mjab043
复制
发表时间：
2021-10-21
影响因子：
5.5
通讯作者：
Yang Q
中科院分区：
文献类型：
--
作者：
Gao W;Liu JL;Lu X;Yang Q
肥胖在全球范围内已达到流行病的程度。虽然现代人久坐不动的生活方式加上能量密集的营养被认为是肥胖流行的主要原因，但遗传介导对肥胖的能量代谢不平衡有重要作用。然而，从大规模遗传研究中发现的遗传位点变异似乎并不能完全解释过去40到50年来肥胖流行病的快速增长。下一代测序技术的最新进展和代谢器官中表观遗传因子的组织特异性作用的研究显著地推进了我们对肥胖中能量代谢的表观遗传调节的理解。表观基因组包括DNA甲基化、组蛋白修饰和RNA介导的过程，其特征在于基因功能的有丝分裂或减数分裂可遗传的变化而不改变DNA序列。重要的是，表观遗传修饰是可逆的。因此，全面了解能量代谢的表观遗传调控的景观可以揭示肥胖治疗的新分子靶点。本文综述了DNA甲基化、组蛋白修饰（如甲基化和乙酰化）以及RNA介导的过程在调节能量代谢中的作用。我们还讨论了生活方式的改变和治疗药物对肥胖症能量代谢的表观遗传调节的影响。
Obesity has reached epidemic proportions globally. Although modern adoption of a sedentary lifestyle coupled with energy-dense nutrition is considered to be the main cause of obesity epidemic, genetic preposition contributes significantly to the imbalanced energy metabolism in obesity. However, the variants of genetic loci identified from large-scale genetic studies do not appear to fully explain the rapid increase in obesity epidemic in the last four to five decades. Recent advancements of next-generation sequencing technologies and studies of tissue-specific effects of epigenetic factors in metabolic organs have significantly advanced our understanding of epigenetic regulation of energy metabolism in obesity. The epigenome, including DNA methylation, histone modifications, and RNA-mediated processes, is characterized as mitotically or meiotically heritable changes in gene function without alteration of DNA sequence. Importantly, epigenetic modifications are reversible. Therefore, comprehensively understanding the landscape of epigenetic regulation of energy metabolism could unravel novel molecular targets for obesity treatment. In this review, we summarize the current knowledge on the roles of DNA methylation, histone modifications such as methylation and acetylation, and RNA-mediated processes in regulating energy metabolism. We also discuss the effects of lifestyle modifications and therapeutic agents on epigenetic regulation of energy metabolism in obesity.
登录
查看更多内容
影响因子：
16
作者：
Calo, Eliezer;Wysocka, Joanna
通讯作者：
Wysocka, Joanna
脂肪组织转录组的从头重建揭示了棕色脂肪细胞发育的长无编码RNA调节剂。
影响因子：
29
作者：
Alvarez-Dominguez JR;Bai Z;Xu D;Yuan B;Lo KA;Yoon MJ;Lim YC;Knoll M;Slavov N;Chen S;Peng C;Lodish HF;Sun L
通讯作者：
Sun L
影响因子：
16.6
作者：
Abe, Yohei;Rozqie, Royhan;Matsumura, Yoshihiro;Kawamura, Takeshi;Nakaki, Ryo;Tsurutani, Yuya;Tanimura-Inagaki, Kyoko;Shiono, Akira;Magoori, Kenta;Nakamura, Kanako;Ogi, Shotaro;Kajimura, Shingo;Kimura, Hiroshi;Tanaka, Toshiya;Fukami, Kiyoko;Osborne, Timothy F.;Kodama, Tatsuhiko;Aburatani, Hiroyuki;Inagaki, Takeshi;Sakai, Juro
通讯作者：
Sakai, Juro
影响因子：
29
作者：
Barres, Romain;Yan, Jie;Zierath, Juleen R.
通讯作者：
Zierath, Juleen R.
影响因子：
3.4
作者：
Beg MS;Brenner AJ;Sachdev J;Borad M;Kang YK;Stoudemire J;Smith S;Bader AG;Kim S;Hong DS
通讯作者：
Hong DS