Mapping value based planning and extensively trained choice in the human brain.

Mapping value based planning and extensively trained choice in the human brain.
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DOI:
10.1038/nn.3068
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发表时间:
2012-03-11
影响因子:
25
通讯作者:
--
中科院分区:
医学1区
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对人类选择的潜在机制的研究集中在从预测错误中学习,因此基于价值的规划的计算结构相对而言探索不足。使用行为和神经影像学分析的极大极小决策任务,我们表明,计算过程的基础上向前规划表示在前尾状核的决策树中的个别分支步骤的值。相比之下,壳核中的值仅与在大量训练中学到的值有关。在实际的选择,这两个纹状体区显示出功能耦合到腹内侧前额叶皮层,作为一个值比较器与此区域一致。我们的研究结果指向一种选择架构,在这种架构中,隔离的价值系统在纹状体中并行运作,用于规划和广泛训练的选择,内侧前额叶皮层整合了它们的输出。
Investigations of the underlying mechanisms of choice in humans have focused on learning from prediction errors, and so the computational structure of value based planning is comparatively underexplored. Using behavioural and neuroimaging analyses of a minimax decision task, we show that the computational processes underlying forward planning are expressed in the anterior caudate nucleus as values of individual branching steps in a decision tree. In contrast, values represented in the putamen pertain solely to values learnt during extensive training. During actual choice, both striatal areas show a functional coupling to ventromedial prefrontal cortex, consistent with this region acting as a value comparator. Our findings point towards an architecture of choice in which segregated value systems operate in parallel in the striatum for planning and extensively trained choices, with medial prefrontal cortex integrating their outputs.
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