Siphonaxanthin, a green algal carotenoid, as a novel functional compound.
Siphonaxanthin, a green algal carotenoid, as a novel functional compound.
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DOI：
10.3390/md12063660
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发表时间：
2014-06-19
期刊：
影响因子：
5.4
通讯作者：
Hirata T
中科院分区：
文献类型：
--
作者：
Sugawara T;Ganesan P;Li Z;Manabe Y;Hirata T
Siphonaxanthin是绿藻中特有的类酮胡萝卜素，其生物功能特性尚未明确。本文综述了虹霓黄质作为一种生物活性化合物，并概述了与功能相关的证据。据报道，Siphonaxanthin通过诱导细胞凋亡有效抑制人白血病HL-60细胞的生存能力。与岩藻黄素相比，早在处理后6 h，虹膜黄素就显著降低了细胞活力。虹膜黄素的细胞吸收量是岩藻黄素的2倍。利用人脐静脉内皮细胞和大鼠主动脉环进行的研究表明，siphonaxanthin具有明显的抗血管生成活性。这些研究结果表明，siphonaxanthin的抗血管生成作用是由于下调血管内皮细胞中成纤维细胞生长因子受体-1的信号转导。Siphonaxanthin对抗原诱导的肥大细胞脱颗粒也有抑制作用。这些发现为进一步研究虹黄质作为一种生物活性化合物开辟了新的途径，需要进一步的研究，特别是体内研究来验证这些发现。此外，还需要进一步的研究来确定其生物利用度和代谢命运。
Siphonaxanthin is a specific keto-carotenoid in green algae whose bio-functional properties are yet to be identified. This review focuses on siphonaxanthin as a bioactive compound and outlines the evidence associated with functionality. Siphonaxanthin has been reported to potently inhibit the viability of human leukemia HL-60 cells via induction of apoptosis. In comparison with fucoxanthin, siphonaxanthin markedly reduced cell viability as early as 6 h after treatment. The cellular uptake of siphonaxanthin was 2-fold higher than fucoxanthin. It has been proposed that siphonaxanthin possesses significant anti-angiogenic activity in studies using human umbilical vein endothelial cells and rat aortic ring. The results of these studies suggested that the anti-angiogenic effect of siphonaxanthin is due to the down-regulation of signal transduction by fibroblast growth factor receptor-1 in vascular endothelial cells. Siphonaxanthin also exhibited inhibitory effects on antigen-induced degranulation of mast cells. These findings open up new avenues for future research on siphonaxanthin as a bioactive compound, and additional investigation, especially in vivo studies, are required to validate these findings. In addition, further studies are needed to determine its bioavailability and metabolic fate.
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