Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms.
Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms.
复制标题
DOI：
10.3390/md11125130
复制
发表时间：
2013-12-16
期刊：
影响因子：
5.4
通讯作者：
Miyashita K
中科院分区：
文献类型：
--
作者：
Kumar SR;Hosokawa M;Miyashita K
岩藻黄质是一种海洋类胡萝卜素，具有多种健康益处。岩藻黄质及其脱乙酰代谢物岩藻黄质醇的抗癌作用已有充分记录。鉴于其强大的抗癌活性，了解其潜在机制的需求已变得尤为突出。为了实现这一目标，一些研究人员在各种细胞系和体内进行了研究，并破译了岩藻黄质通过不同的分子和途径发挥其抗增殖和癌症预防作用，包括Bcl-2蛋白、MAPK、NFκB、半胱天冬酶、GADD45和其他几种参与细胞周期停滞、凋亡或转移的分子。因此，除了降低肿瘤发生和生长的频率外，岩藻黄质对癌细胞还具有细胞毒性作用。一些研究表明，这种作用是选择性的，即岩藻黄质具有仅针对癌细胞的能力，而使正常的生理细胞不受影响/受影响较小。因此，岩藻黄质及其代谢物作为癌症化疗药物显示出巨大的前景。
Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving this goal, several researchers have carried out studies in various cell lines and in vivo and have deciphered that fucoxanthin exerts its anti-proliferative and cancer preventing influence via different molecules and pathways including the Bcl-2 proteins, MAPK, NFκB, Caspases, GADD45, and several other molecules that are involved in either cell cycle arrest, apoptosis, or metastasis. Thus, in addition to decreasing the frequency of occurrence and growth of tumours, fucoxanthin has a cytotoxic effect on cancer cells. Some studies show that this effect is selective, i.e., fucoxanthin has the capability to target cancer cells only, leaving normal physiological cells unaffected/less affected. Hence, fucoxanthin and its metabolites show great promise as chemotherapeutic agents in cancer.
登录
查看更多内容
DOI：
10.1111/j.1349-7006.1999.tb00836.x
发表时间：
1999-09
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Funahashi H;Imai T;Tanaka Y;Tsukamura K;Hayakawa Y;Kikumori T;Mase T;Itoh T;Nishikawa M;Hayashi H;Shibata A;Hibi Y;Takahashi M;Narita T
通讯作者：
Narita T
影响因子：
3.9
作者：
Fahmi, Odette A.;Kish, Mary;Obach, R. Scott
通讯作者：
Obach, R. Scott
DOI：
10.1016/j.bbagen.2008.01.003
发表时间：
2008-04-01
影响因子：
3
作者：
Das, Swadesh K.;Hashimoto, Takashi;Kanazawa, Kazuki
通讯作者：
Kanazawa, Kazuki
影响因子：
56.9
作者：
Johnson, GL;Lapadat, R
通讯作者：
Lapadat, R
影响因子：
8.8
作者：
Chandini, S. Kumar;Ganesan, P.;Bhaskar, N.
通讯作者：
Bhaskar, N.