Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder.
Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder.
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DOI：
10.1038/s41398-022-01791-7
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发表时间：
2022-01-21
影响因子：
6.8
通讯作者：
Gong Q
中科院分区：
文献类型：
--
作者：
Zhang X;Suo X;Yang X;Lai H;Pan N;He M;Li Q;Kuang W;Wang S;Gong Q
尽管在社交焦虑障碍（SAD）患者中观察到了与恐惧和焦虑的神经生物学有关的脑区的功能和结构异常，但由于样本量小、人口统计学混杂因素和方法学差异，研究结果是异质性的。此外，多模态神经影像学研究的结构功能缺陷和耦合是相当稀缺的。在此，我们的目的是探索具有结构缺陷的大脑区域的功能网络异常以及结构-功能耦合对SAD诊断的影响。高分辨率结构磁共振成像（MRI）和静息态功能MRI图像来自49名非共病SAD患者和53名人口统计学匹配的健康对照。进行了全脑基于体素的形态学分析，以调查结构的变化，随后被用作种子的静息态功能连接分析。此外，还进行了相关性和中介分析，以探讨结构功能缺陷在SAD诊断中的潜在作用。SAD患者双侧壳核、右侧丘脑和左侧海马旁灰质体积显著减少。此外，SAD患者表现出广泛的皮质-纹状体-丘脑-小脑回路的静息状态连接障碍。此外，壳核与小脑和右侧丘脑与颞中回/辅助运动区的连接障碍部分介导了壳核/丘脑萎缩对SAD诊断的影响。我们的研究结果提供了初步的证据参与的皮质-纹状体-丘脑-小脑回路的结构和功能缺陷，并可能有助于澄清SAD的结构-功能耦合的潜在机制。因此，他们可以提供深入了解SAD的神经生物学基础。
Although functional and structural abnormalities in brain regions involved in the neurobiology of fear and anxiety have been observed in patients with social anxiety disorder (SAD), the findings have been heterogeneous due to small sample sizes, demographic confounders, and methodological differences. Besides, multimodal neuroimaging studies on structural-functional deficits and couplings are rather scarce. Herein, we aimed to explore functional network anomalies in brain regions with structural deficits and the effects of structure-function couplings on the SAD diagnosis. High-resolution structural magnetic resonance imaging (MRI) and resting-state functional MRI images were obtained from 49 non-comorbid patients with SAD and 53 demography-matched healthy controls. Whole-brain voxel-based morphometry analysis was conducted to investigate structural alterations, which were subsequently used as seeds for the resting-state functional connectivity analysis. In addition, correlation and mediation analyses were performed to probe the potential roles of structural-functional deficits in SAD diagnosis. SAD patients had significant gray matter volume reductions in the bilateral putamen, right thalamus, and left parahippocampus. Besides, patients with SAD demonstrated widespread resting-state dysconnectivity in cortico-striato-thalamo-cerebellar circuitry. Moreover, dysconnectivity of the putamen with the cerebellum and the right thalamus with the middle temporal gyrus/supplementary motor area partially mediated the effects of putamen/thalamus atrophy on the SAD diagnosis. Our findings provide preliminary evidence for the involvement of structural and functional deficits in cortico-striato-thalamo-cerebellar circuitry in SAD, and may contribute to clarifying the underlying mechanisms of structure-function couplings for SAD. Therefore, they could offer insights into the neurobiological substrates of SAD.
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影响因子：
--
作者：
Atmaca, Murad;Koc, Mustafa;Yildirim, Hanefi
通讯作者：
Yildirim, Hanefi
影响因子：
4.2
作者：
Bas-Hoogendam, Janna Marie;van Steenbergen, Henk;van der Wee, Nic J. A.
通讯作者：
van der Wee, Nic J. A.
影响因子：
4.8
作者：
Bas-Hoogendam JM;Groenewold NA;Aghajani M;Freitag GF;Harrewijn A;Hilbert K;Jahanshad N;Thomopoulos SI;Thompson PM;Veltman DJ;Winkler AM;Lueken U;Pine DS;van der Wee NJA;Stein DJ;ENIGMA-Anxiety Working Group
通讯作者：
ENIGMA-Anxiety Working Group
影响因子：
11.1
作者：
Bas-Hoogendam JM;van Steenbergen H;Cohen Kadosh K;Westenberg PM;van der Wee NJA
通讯作者：
van der Wee NJA
影响因子：
17.7
作者：
Chavanne, Alice, V;Robinson, Oliver J.
通讯作者：
Robinson, Oliver J.