Biosynthesis of the potent carcinogen 7,12-dimethylbenz[a]anthracene.
Biosynthesis of the potent carcinogen 7,12-dimethylbenz[a]anthracene.
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强效致癌物 7,12-二甲基苯并[a]蒽的生物合成。
DOI：
10.1016/0304-3835(84)90031-4
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发表时间：
1984
期刊：
影响因子：
9.7
通讯作者：
Blake,JW
中科院分区：
文献类型：
--
作者：
Flesher,JW;Myers,SR;Blake,JW
Earlier studies from this laboratory of the metabolism of 7,12-dimethylbenz[a]anthracene (DMBA) and of benzo[a]pyrene as well as studies of mutagenic and carcinogenic activity of some of the metabolic products led to the concept that a necessary first step in carcinogenesis by most alkyl substituted polycyclic hydrocarbons is biotransformation to a meso-anthracenic hydroxyalkyl metabolite [5], whereas most hydrocarbons lacking alkyl substituents undergo a bio-alkylation substitution reaction in the mesoanthracenic positions(s) or L-region as a necessary first step in carcinogenesis [6]. According to this unified hypothesis, all strong polycyclic hydrocarbon carcinogens must either, themselves, bear a meso-anthracenic alkyl substituent or else undergo a bio-alkylation substitution reaction in vitro and in vivo. Here we report that the weak carcinogen benz[a]anthracene undergoes meso-anthracenic methylation byS-adenosyl-l-methionine (SAM), in the presence of a rat liver cytosol preparation, in vitro, to form DMBA and presumably the moderately active carcinogens 7-methylbenz[a]anthracene and 12-methylbenz[a]anthracene. These compounds are substrates for further L-region methylation to form the strong carcinogen, DMBA.
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DOI：
--
发表时间：
1985-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
J. Vanderhoek;M. Karmin;S. Ekborg
通讯作者：
J. Vanderhoek;M. Karmin;S. Ekborg
吲哚美辛、乙炔酸、15-HETE、去甲二氢愈创木酸和 BW755C 对人白细胞和血小板中花生四烯酸代谢的影响比较。
DOI：
--
发表时间：
1984
期刊：
Prostaglandins Leukotrienes and Medicine
影响因子：
--
作者：
Hassan Salari;Pierre Braquet;P. Borgeat
通讯作者：
P. Borgeat
15-脂氧合酶衍生的花生四烯酸代谢物对人中性粒细胞脱颗粒的影响。
DOI：
10.1016/0262-1746(85)90107-6
发表时间：
1985
期刊：
Prostaglandins, leukotrienes, and medicine
影响因子：
--
作者：
J. O’Flaherty;Michael J. Thomas
通讯作者：
Michael J. Thomas
影响因子：
2.9
作者：
SERHAN, CN;WONG, PYK;SAMUELSSON, B
通讯作者：
SAMUELSSON, B
磷脂酶 A2 同工酶可激发猪白细胞内源性花生四烯酸形成脂氧素 B。
DOI：
10.1016/s0006-291x(87)80484-9
发表时间：
1987
影响因子：
3.1
作者：
Lam,BK;Serhan,CN;Samuelsson,B;Wong,PY
通讯作者：
Wong,PY