Inter-subject correlation exists between morphological metrics of cerebral blood flow velocity and intracranial pressure pulses.
Inter-subject correlation exists between morphological metrics of cerebral blood flow velocity and intracranial pressure pulses.
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DOI：
10.1007/s12028-010-9471-x
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发表时间：
2011-04
影响因子：
3.5
通讯作者：
Vespa, Paul
中科院分区：
文献类型：
--
作者：
Kim, Sunghan;Hu, Xiao;McArthur, David;Hamilton, Robert;Bergsneider, Marvin;Glenn, Thomas;Martin, Neil;Vespa, Paul
关键词：
众所周知，典型的颅内压（ICP）脉冲形态是三相的。一些研究表明，ICP脉冲的形态反映了颅内动力学的生理和病理生理条件。最近，在各种临床背景下，使用新的ICP信号处理技术研究ICP脉冲已经复兴。脑血流速度（CBFV）脉冲是另一种重要的脉动信号，来源于复杂的脑血流循环系统。然而，CBFV脉冲形态没有得到很好的研究，主要是由于噪声水平和缺乏信号处理技术。我们小组最近开发了一种称为颅内压形态聚类和分析（MOCAIP）的技术，可以提取一组全面的脉搏形态指标。我们扩展此算法提取各种形态指标，同时记录从47例脑损伤患者的ICP和CBFV脉冲，并利用强大的百分比弯曲相关性分析这些指标之间的相互关系进行调查。我们的研究结果表明，CBFV脉冲也是三相的ICP脉冲和15.2%的128脉冲形态指标提取ICP和CBFV脉冲是高度相关的（p<0.01），在一个受试者间的方式。此外，平均ICP与CBFV脉冲的脉动指数不相关（p=0.45），但与几种新的CBFV脉冲形态指标相关（p<0.05），例如CBFV脉冲开始与ECG QRS峰值之间的时间间隔。我们的研究结果表明，表征CBFV脉冲形态在临床上很重要，因为它可能提供一种潜在的非侵入性替代方法来评估ICP的各个方面，如平均ICP。
The prototypical intracranial pressure (ICP) pulse morphology has been well known to be triphasic. Several studies suggest that the morphology of ICP pulse reflects the physiological and pathophysiological conditions of the intracranial dynamics. Recently, there has been a renaissance of studying ICP pulse using new ICP signal processing technologies in various clinical contexts. Cerebral blood flow velocity (CBFV) pulse is another important pulsatile signal originated from the complex circulatory systems of cerebral blood flow. However, CBFV pulse morphology has not been well studied mainly due to the noise level and lack of signal processing techniques. Our group recently developed a technique called the Morphological Clustering and Analysis of Intracranial Pressure (MOCAIP) that can extract a comprehensive set of pulse morphological metrics. We extend this algorithm to extract various morphological metrics from ICP and CBFV pulses that were simultaneously recorded from 47 brain injury patients and investigate the mutual correlation between those metrics utilizing the robust percentage bend correlation analysis. Our results show that CBFV pulses are also triphasic as ICP pulses and 15.2% of 128 pulse morphological metrics extracted from ICP and CBFV pulses are highly correlated (p<0.01) in an inter-subject fashion. In addition, mean ICP does not correlate (p=0.45) with the pulsatility index of CBFV pulses but correlates (p<0.05) with several novel CBFV pulse morphological metrics such as the time interval between the onset of CBFV pulses and ECG QRS peak. Our results suggest that characterizing CBFV pulse morphology is clinically important because it may offer a potential noninvasive alternative to assess various aspects of ICP such as mean ICP.
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DOI：
10.1109/tbme.2008.2008636
发表时间：
2009-03
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Hu X;Xu P;Scalzo F;Vespa P;Bergsneider M
通讯作者：
Bergsneider M
影响因子：
3
作者：
CONTANT, CF;ROBERTSON, CS;GROSSMAN, RG
通讯作者：
GROSSMAN, RG
影响因子：
8.3
作者：
Nagai, H;Moritake, K;Takaya, M
通讯作者：
Takaya, M
影响因子：
8.3
作者：
EKELUND, A;SAVELAND, H;BRANDT, L
通讯作者：
BRANDT, L
影响因子：
4.8
作者：
Behrens, Anders;Lenfeldt, Niklas;Koskinen, Lars-Owe
通讯作者：
Koskinen, Lars-Owe