Access to P-stereogenic compounds via desymmetrizing enantioselective bromination.
Access to P-stereogenic compounds via desymmetrizing enantioselective bromination.
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通过对映选择性溴化的对称对映选择性溴化，可以访问P-肌发育化合物。
DOI：
10.1039/d0sc07008d
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发表时间：
2021-02-12
期刊：
影响因子：
8.4
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Huang QH;Zhou QY;Yang C;Chen L;Cheng JP;Li X
A novel and efficient desymmetrizing asymmetric ortho-selective mono-bromination of bisphenol phosphine oxides under chiral squaramide catalysis was reported. Using this asymmetric ortho-bromination strategy, a wide range of chiral bisphenol phosphine oxides and bisphenol phosphinates were obtained with good to excellent yields (up to 92%) and enantioselectivities (up to 98.5 : 1.5 e.r.). The reaction could be scaled up, and the synthetic utility of the desired P-stereogenic compounds was proved by transformations and application in an asymmetric reaction. A highly efficient desymmetrizing asymmetric bromination of bisphenol phosphine oxides was developed, providing a wide range of chiral bisphenol phosphine oxides and bisphenol phosphinates with high yields and enantioselectivities.
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影响因子：
16.6
作者：
Jang, Yun-Suk;Wozniak, Lukasz;Cramer, Nicolai
通讯作者：
Cramer, Nicolai
影响因子：
15
作者：
Beaud R;Phipps RJ;Gaunt MJ
通讯作者：
Gaunt MJ
DOI：
10.1126/science.1188403
发表时间：
2010-06-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gustafson JL;Lim D;Miller SJ
通讯作者：
Miller SJ
影响因子：
15
作者：
Bergin, Enda;O'Connor, Cormac T.;Gilheany, Declan G.
通讯作者：
Gilheany, Declan G.
影响因子：
1.8
作者：
Iseki, K;Kuroki, Y;Kobayashi, Y
通讯作者：
Kobayashi, Y