Right-lateralized brain oscillations in human spatial navigation.

Right-lateralized brain oscillations in human spatial navigation.
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DOI:
10.1162/jocn.2009.21240
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发表时间:
2010-05
影响因子:
3.2
通讯作者:
Kahana MJ
Kahana MJ
中科院分区:
医学3区
文献类型:
--
作者:
Jacobs J;Korolev IO;Caplan JB;Ekstrom AD;Litt B;Baltuch G;Fried I;Schulze-Bonhage A;Madsen JR;Kahana MJ

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在空间导航过程中,病变和功能成像研究表明右半球具有独特的功能作用。然而,对人类大脑直接记录的研究尚未报告与导航相关的振荡活动的半球间差异。我们使用 24 名神经外科患者玩虚拟出租车司机游戏的颅内脑电图记录来研究这种明显的差异。当患者在游戏中虚拟移动时,与虚拟静止时期相比,不同频率的大脑振荡幅度会增加。使用对数线性分析,我们分析了该模式的区域和频率特异性,发现新皮质运动相关的伽玛振荡(34-54 Hz)显着偏向于右半球,特别是在后新皮质中。我们还观察到与在未知虚拟位置搜索物体相关的伽马振荡的类似右侧化。因此,我们的结果表明,右侧新皮质的伽马振荡在人类空间导航中发挥着特殊作用。
During spatial navigation, lesion and functional imaging studies suggest that the right hemisphere has a unique functional role. However, studies of direct human brain recordings have not reported interhemisphere differences in navigation-related oscillatory activity. We investigated this apparent discrepancy using intracranial electroencephalographic recordings from 24 neurosurgical patients playing a virtual taxi driver game. When patients were virtually moving in the game, brain oscillations at various frequencies increased in amplitude compared with periods of virtual stillness. Using log-linear analysis, we analyzed the region and frequency specificities of this pattern and found that neocortical movement-related gamma oscillations (34–54 Hz) were significantly lateralized to the right hemisphere, especially in posterior neocortex. We also observed a similar right lateralization of gamma oscillations related to searching for objects at unknown virtual locations. Thus, our results indicate that gamma oscillations in the right neocortex play a special role in human spatial navigation.
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