Physiology and Endocrinology of the Ovarian Cycle in Macaques.
Physiology and Endocrinology of the Ovarian Cycle in Macaques.
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DOI：
10.1177/0192623308327412
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发表时间：
2008-12
影响因子：
1.5
通讯作者：
Cline JM
中科院分区：
文献类型：
--
作者：
Weinbauer GF;Niehoff M;Niehaus M;Srivastav S;Fuchs A;Van Esch E;Cline JM
猕猴为雌性生殖毒物的临床前测试和安全性评估提供了优秀的模型。目前，食蟹猴是（生殖）毒性测试的主要物种。狨猴和恒河猴偶尔也会被使用。作者对食蟹猴卵巢周期的生理学和内分泌学进行了简要回顾，评估和监测卵巢周期的实用指导，以及毒理学研究中社会住房对卵巢周期影响的新数据。在猕猴中，周期监测是通过每日阴道涂片检查月经并结合按周期频繁采样进行类固醇和肽激素分析来实现的。由于需要频繁和定时采血，不建议将这些特殊评估纳入一般毒性研究设计中。狨猴缺乏卵巢周期的外部迹象，周期监测是通过定期测定黄体酮来完成的。食蟹猴和狨猴的卵巢活动不表现出季节性变化，而这种年度节律在恒河猴中却很明显。对配对和群养食蟹猴的研究表明，卵巢周期的持续时间和内分泌发生了短暂的变化，大约六个月后恢复到正常周期。如果动物在混合之前彼此接触过，就可以避免这种效应。这些实验还表明，卵巢周期并未发生同步。
Macaques provide excellent models for preclinical testing and safety assessment of female reproductive toxicants. Currently, cynomolgus monkeys are the predominant species for (reproductive) toxicity testing. Marmosets and rhesus monkeys are being used occasionally. The authors provide a brief review on physiology and endocrinology of the cynomolgus monkey ovarian cycle, practical guidance on assessment and monitoring of ovarian cyclicity, and new data on effects of social housing on ovarian cyclicity in toxicological studies. In macaques, cycle monitoring is achieved using daily vaginal smears for menstruation combined with cycle-timed frequent sampling for steroid and peptide hormone analysis. Owing to requirements of frequent and timed blood sampling, it is not recommended to incorporate these special evaluations into a general toxicity study design. Marmosets lack external signs of ovarian cyclicity, and cycle monitoring is done by regular determinations of progesterone. Cynomolgus and marmoset monkeys do not exhibit seasonal variations in ovarian activity, whereas such annual rhythm is pronounced in rhesus monkeys. Studies on pair- and group-housed cynomolgus monkeys revealed transient alterations in the duration and endocrinology of the ovarian cycle followed by return to normal cyclicity after approximately six months. This effect is avoided if the animals had contact with each other prior to mingling. These experiments also demonstrated that synchronization of ovarian cycles did not occur.
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影响因子：
3.6
作者：
Gromoll, J;Wistuba, J;Simoni, M
通讯作者：
Simoni, M
影响因子：
2.5
作者：
Archer, DF
通讯作者：
Archer, DF
影响因子：
5.8
作者：
Dickson, SE;Fraser, HM
通讯作者：
Fraser, HM
影响因子：
6.1
作者：
Butterstein, GM;Mann, DR;Castracane, VD
通讯作者：
Castracane, VD
影响因子：
6.1
作者：
Duffy, DM;Stouffer, RL
通讯作者：
Stouffer, RL