Corticospinal Pathways and Interactions Underpinning Dexterous Forelimb Movement of the Rodent.
Corticospinal Pathways and Interactions Underpinning Dexterous Forelimb Movement of the Rodent.
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DOI：
10.1016/j.neuroscience.2020.05.050
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发表时间：
2020-12-01
期刊：
影响因子：
3.3
通讯作者：
Yoshida Y
中科院分区：
文献类型：
--
作者：
Basista MJ;Yoshida Y
2013年，托马斯·杰塞尔（Thomas Jessell）与安德鲁·米里（Andrew Miri）和艾曼·阿齐姆（Eiman Azim）发表了一篇论文，承担了检查运动过程中皮质脊髓神经元功能的任务。他们认为，结合多种方法将能够揭示皮质脊髓功能，并且必须在皮质脊髓与脊髓回路的连接性背景下考虑这种功能。在这篇综述中，我们将重点介绍该领域的最新进展，以及有关皮质脊髓回路与啮齿动物中枢神经系统其他回路的输入和交叉连接的新信息。这些动物中可用的遗传和病毒操作使人们对下行回路相互作用和功能有了新的认识。由于有助于灵巧前肢运动的电路轮廓存在物种差异，突出一个模型的重要进展可能有助于与其他模型的已知情况进行比较和对比。我们将重点关注支撑灵巧前肢运动的电路，包括皮质脊髓束以外的系统的一些最新进展，以更全面地了解感觉运动电路及其对随意运动的控制。因此，啮齿动物皮质脊髓系统是本次综述的中心参考点，但不是唯一的焦点。
In 2013, Thomas Jessell published a paper with Andrew Miri and Eiman Azim that took on the task of examining corticospinal neuron function during movement. They took the view that a combination of approaches would be able to shed light on corticospinal function, and that this function must be considered in the context of corticospinal connectivity with spinal circuits. In this review, we will highlight recent developments in this area, along with new information regarding inputs and cross-connectivity of the corticospinal circuit with other circuits across the rodent central nervous system. The genetic and viral manipulations available in these animals have led to new insights into descending circuit interaction and function. As species differences exist in the circuitry profile that contributes to dexterous forelimb movements, highlighting important advances in one model could help to compare and contrast with what is known about other models. We will focus on the circuitry underpinning dexterous forelimb movements, including some recent developments from systems besides the corticospinal tract, to build a more holistic understanding of sensorimotor circuits and their control of voluntary movement. The rodent corticospinal system is thus a central point of reference in this review, but not the only focus.
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